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Dermatology > Pemphigous Vulgaris > Flashcards

Pemphigous Vulgaris Flashcards

1
Q

Pemphigus vulgaris definition

A

Intraepidermal blisters on skin and mucous

Autoantibodies against desmogleins 3

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2
Q

Pathogenesis

A

Autoantibodies (IgG) against desmoglein
Desmosome damage
Genetic
Drugs (sulfhydryl groups)

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3
Q

Clinical features

A

Oral mucosa
Scalp
Face
Nail folds
Intertriginous areas
Ulcers
Erosions
Crust

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4
Q

Are the blisters stable?

A

No
Erosions
Crust are common

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5
Q

The stages

A

Oral
Scalp
Generalised

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6
Q

Is pemphigus vulgaris pruritic?

A

No uncommon

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7
Q

Nikolsky sign in pemphigus is

A

Positive and there is also pseudo nikolsky sign

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8
Q

Pseudo nikolsky sign is

A

Spreading of blister after lateral pressure on blister

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9
Q

Diagnosis

A

Immunofluorescence
ELISA
Histology

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10
Q

Differential diagnosis

A

Oral candidiasis
Bullous impetigo

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11
Q

Therapy

A

Systemic corticosteroids
Prednisolone
Azathioprine

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Dermatology (31 decks)

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