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Flashcards in Pestana Transplantation Deck (6):

What is the ONLY absolute contraindication for organ donation?

Positive HIV status


Pathophysiology of hyperacute rejection? Prevention?

Vascular thrombosis to the organ by preformed antibodies within minutes of implantation. Never happens because all organs undergo ABO matching and Lymphocytotoxic crossmatching.


Signs of acute liver rejection? What must be ruled out? Treatment?

Rising GGT, alkaline phosphatase, and bilirubin. Rule out biliary obstruction by ultrasound and vascular thrombosis by Doppler.


How are heart transplants monitored to see if they develop acute rejection?

Ventricular biopsies of the jugular, superior vena cava, and right atrium at set intervals.


Timeline and Treatment of acute rejection?

5 days to 3 months. Steroid bolus.


Timeline and Treatment of chronic rejection?

Years after transplant. No real therapy, just slow decline of organ function.