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Flashcards in Pestana Transplantation Deck (6):
1

What is the ONLY absolute contraindication for organ donation?

Positive HIV status

2

Pathophysiology of hyperacute rejection? Prevention?

Vascular thrombosis to the organ by preformed antibodies within minutes of implantation. Never happens because all organs undergo ABO matching and Lymphocytotoxic crossmatching.

3

Signs of acute liver rejection? What must be ruled out? Treatment?

Rising GGT, alkaline phosphatase, and bilirubin. Rule out biliary obstruction by ultrasound and vascular thrombosis by Doppler.

4

How are heart transplants monitored to see if they develop acute rejection?

Ventricular biopsies of the jugular, superior vena cava, and right atrium at set intervals.

5

Timeline and Treatment of acute rejection?

5 days to 3 months. Steroid bolus.

6

Timeline and Treatment of chronic rejection?

Years after transplant. No real therapy, just slow decline of organ function.