Pharm Drug Suffixes (from DIT)

Question 1

-afil

Answer 1

phosphodiesterase inhibitor

sildenafil, tadafil

Question 2

-azepam

Answer 2

benzodiazepine

lorazepam, diazepam

Question 3

-azine

Answer 3

phenothiazine

chlorpromazine, thioridazine (neuroleptic), promethazine (anti-emetic)

Question 4

-azolam

Answer 4

benzodiazepine

alprazolam, midazolam, triazolam

Question 5

-barbital

Answer 5

barbiturate

phenobarbital, secobarbital

Question 6

-bendazole

Answer 6

benzimidazole (worm, parasite)

mebendazole, albendazole

Question 7

-caine

Answer 7

local anesthetics

lidocaine, tetracaine

Question 8

-chol

Answer 8

muscarinic agonist

bethanechol, carbachol

Question 9

-cillin

Answer 9

penicillin

amoxicillin, methicillin

Question 10

-conazole

Answer 10

imidazole (antifungal)

fluconazole, ketoconazole

Question 11

-curium

Answer 11

non-depolarizing neuromuscular block

atracurium, mivacurium

Question 12

-curonium

Answer 12

non-depolarizing neuromuscular blocker

vecuronium, rocuronium*

Question 13

-cycline

Answer 13

protein synthesis inhibitor

tetracycline, doxycycline

Question 14

-dipine

Answer 14

dihydropyridine calcium channel blocker

nifedipine, amlodipine

Question 15

-dronate

Answer 15

bisphosphonate (tx osteoporosis)

alendronate, risedronate

Question 16

-etine

Answer 16

SSRI

fluoxetine, paroxetine, sertraline

Question 17

-flurane

Answer 17

Inhaled anesthetics

isoflurane, sevoflurane

Question 18

-gliptin

Answer 18

DPP-IV inhibitor (tx DM)

sitagliptin, saxagliptin

Question 19

-glitazone

Answer 19

thiazolidinedione (tx DM) (increase insulin sensitivity)

pioglitazone, rosiglitazone

Question 20

-ipramine

Answer 20

TCA

clomipramine, imipramine

Question 21

-mab

Answer 21

monoclonal antibody

infliximab, rituximab

Question 22

-mustine

Answer 22

nitrosourea (nitrogen mustard) - CA drugs, cross BBB and tx BBB (therefore, SFx = CNS)
lomustine

Question 23

-navir

Answer 23

protease inhibitor (HIV tx)
ritonavir (p450 inhibitor), saquinavir

Question 24

-olol

Answer 24

B-blocker
atenolol, metoprolol
(labetalol, carvediolol (also block A R’s))

Question 25

-operidol

Answer 25

neuroleptic

haloperidol, droperidol

Question 26

-phylline

Answer 26

methylxanthine

theophylline, aminophylline

Question 27

-pril

Answer 27

ACE inhibitor

enalapril, lisinopril

Question 28

-prost

Answer 28

prostaglandin analog

latanoprost, travoprost (tx glaucoma)

Question 29

-sartan

Answer 29

Angiotensin receptor blocker

losartan, valsartan

Question 30

-stigmine

Answer 30

anticholinesterase (indirect cholinergic agonist)

neostigmine, physostigmine, rivastigmine (tx AD)

Question 31

-terol

Answer 31

B2-agonist

albuterol, salmeterol

Question 32

-tidine

Answer 32

H2 histamine antagonist

cimetidine, ranitidine

Question 33

-triptan

Answer 33

5-HT(1B/1D) agonist -SER agonist, tx migraines

sumatriptan, rizatriptan

Question 34

-triptyline

Answer 34

TCA
amitriptyline, nortriptyline
(other TCA -ipramine)

Question 35

-tropin

Answer 35

Pituitary hormone

somatotropin, thyrotropin (TSH)

Question 36

-zosin

Answer 36

A1-antagonist

prazosin, doxazosin

Question 37

-statin

Answer 37

HMG-CoA reductase inhibitor

atorvastatin, simvastatin

Question 38

-asteride

Answer 38

5 alpha reductase inhibitors
-finasteride
(tx BPH, alopecia)

Question 39

-“ine” ex: bromocriptine

Answer 39

DA agonist drug - inhibits prolactin secretion

Question 40

“curarine”

Answer 40

non-depolarizing neuromuscular blocker

Question 41

Inhaled anesthetics:
blood vs lipid solubility
min alveolar concentration
drugs

Answer 41

blood solubility - less soluble = inc potency
lipid solubility - more soluble = cross BBB inc potency

MAC - amt needed for 50% people feel pain

NO - low blood / low lipid solubility
halothane - don’t use, hepatotoxicity
sevoflurane, desflurane - low blood, low lipid #1 used
isoflurane - moderate blood and lipid solubilty

Question 42

IV anesthetics:
GABA and opioid R
propofol
ketamine
barbiturates
benzodiazepines
opioids

Answer 42

no analgesia
sedative hypnotic
propofol - rapid, high triglycerides
ketamine - dissociative anesthetic, *inc cerebral BF

barbiturates
“want bars to stay open longer with less lines (CSF)”
“itol” “lol” (above = thiopental)
work on GABA, inc duration Cl- channel open
decrease cerebral BF
phenobarbital - inc liver enzymes, tx crigler-najjar

benzodiazepines
"azolam" "azapram"
GABA, inc frz Cl- channels open
     -midazolam = short procedure, conscious sedation
     -chlordiazepoxide = tx alcohol
Tx OD with Flumazenil 

opioids - analgesia
mu - beta-endorphin
delta - encephalin
kappa - dynorphin
Butorphanol - less resp depression
Dextromethorphan - cough suppression (OTC)
Tramadol - analgesia
Loperamide/Diphenoxylate - tx diarrhea
Fentenyl - no histamine release (vs morphine)
Tx OD - naloxone, naltrexone

Question 43

NMJ blocking agents - immobility:
non-depolarizing
depolarizing

Answer 43

non-depolarizing:
competitive inhibitors nicotinic Ach R, can reverse with ChE inhibitor
“curium” “curonium” “curarine”

depolarizing: –succinylcholine
binds nicotinic R with initial muscle contraction then stops
phase 1 - low does, no reverse
phase 2 - high does, can rev with AchE inhibitor
**succinylcholine + inhaled anesthetic in pt with RYR 1 MT -> malignant hyperthermia, tx with Dantrolene

Question 44

Local anesthetic

Answer 44

blocks Na+ channel
lidocaine
1 - worse with acid/inf, need more 
2 - order of sedation:
small myelinated (sensory) > small unmyelindated (SNS)> large myelinated (motor)
*size is more important factor
3 - give with vasoconstrictor at non-block pts 
    (dec BF, use less and no bleed)