Pharm First Aid Toxicities and Side-Effects Flashcards
(72 cards)
1
Q
treatment for Acetominiophen
A
N-acteylcystine (releplenises glutahione)
2
Q
AChE inhbitors, organophosphates OD
A
atropine followed by pralidoxime
3
Q
Amphetamine (basic) OD
A
NH4Cl (acidify urine)
4
Q
antimuscarinics, anticholingeric agents OD
A
physostigme salicylate, control HTN
5
Q
Benzodiazepine OD
A
flumazenil
6
Q
beta blocker OD
A
glucagon (glucagon stimulate adenylyl cyclase and increases intracellular cAMP in many different tissues. In the heart this result in increase of heart rate and force of contraction:)
7
Q
Carbon Monoxide OD
A
100% O2 and Hyperbaric O2
8
Q
copper, arsenic gold OD
A
penicillamine
9
Q
cyanide OD
A
nitrite+thiosulfate, hydroxocarbalamin
10
Q
digitalis OD
A
anti-dig Fab fragments
11
Q
heparin OD
A
protamine sulfate
12
Q
iron OD
A
deferoxamine, deferasirox
13
Q
Lead OD
A
EDTA, dimercaperol, succinmer, penicillamine
14
Q
Mercury, arsenic gold OD
A
dimercaperol (BAL), succimer
15
Q
methanol, ethlyene glycol (antifreeze) OD
A
fomepizole >ethanol, dialysis
16
Q
methemoglobin OD
A
methylene blue, vit C
17
Q
opiods OD
A
naloxone
18
Q
salicylates OD
A
NaHCO3 (alkalinize urine), dialysis
19
Q
TCAs OD
A
NaHCO3 (plasma alkalinization)
20
Q
tPA, streptokinase, urokinase OD
A
aminocaproic acid
21
Q
Warfarin OD
A
vit K, plasmis (if active bleeding)
22
Q
CV: 3 drugs that cause vasospasm
A
cocaine, sumatriptan, ergot alkaloids (bromocriptine)
23
Q
CV: 4 D that cause cutaneous flushing
A
VANC, vancomycin, adenosine, niacin, Ca2+ channel blockers
24
Q
CV: 2 drugs that cause dilated cardiomyopathy
A
doxorubicin, danorubicin
25
CV: 7 Ds that cause torsades de pointes
class III (i.e. sotalol), class IA (quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs
26
Endo/Repro: 1 D that causes andrenocortical insufficiency
HPA suppression secondary to glucoccorticoid withdrawl
27
Endo/Repro: 2 D that cause hot flashes
tamoxifen, clomiphene
28
Endo/Repro: 6 D that cause hyperglycemina
taking pills necessitates having blood checked
| tacrolimus, protease inhbiitors, niacin, HCTZ, beta blockers, corticosteriods
29
Endo/Repro: 3 Ds that cause hypothyroidism
lithium, amiodarone, sulfonamides
30
GI: 1 D that causes acute cholestatic hepattitis
erythromycin
31
GI 5 D that cause diarrehea
metformin, erythromycin, colchicine, orlistat, acarbose (might excrete colon on accident)
32
GI: 4 drugs that cause focal to massive hepatic necrosis
halothane, amanita phalloides (death cap mushroom), valproic acid, aceteaminphen- (Liver HAVAc)
33
GI 1 drug that causes Hepatitis
INH
34
GI: 6 drugs that case pancreatitis
Drugs causing a violent abdominal ditress
| didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics (furosemides, HCTZ)
35
GI: 3 Ds and 1 bacteria that cause pseudomembraneous colitis
clindamycin, ampicillin, cephalsporins- antibiotics predispose to superinfection by resistance c. difficile
36
Heme: 6 Ds that cause agranulocytosis
Drugs CCCrush, Myeloblasts, and Promyelocytes
| dapsone, clozapine, carbamazepine, colchicine, methimazole, propylthiouracil
37
Heme: 6 Ds that cause aplastic anemia
can't make new blood cells properly
| carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil
38
Heme: 2 Ds that cause direct-coombs positive hemolytic anemia
methyldopa, penicillin
39
Heme: 1 D that causes gray baby syndrome
chloramphenicol
40
Heme: 7 Ds that cause hemolysis in G6PD def
Hemolysis IS D PAIN
| INH, sulfonamides, dapsone, primaquine, asprin, ibuprofen, nitrofurantoin
41
Heme: 3 Ds that causes megaloblastic anemia
having a blast with PMS
| phenytoin, methotrexate, sulfa drugs
42
Heme: 2 Ds that cause thrombocytopenia
heparine, cimetidine
43
Heme: 2 Ds that cause thrombotic compications
OCPs (estrogen)
44
Neuro: 2 Ds that cause cinchonism
quinidine, quinine
45
Neuro: 3 Ds that cause Parkinson like syndrome
cogwheel rigidity of ARM
| antipsychotics, reserpine, metoclopramide
46
Neuro: 6 drugs that cause seizures
with seizures I BITE My toungue
| INH (vit B6 def), bupropin, imipenem/cilastatin, tramadol, enflurane, metclopramide
47
Neuro: 2 Ds that cause tardive dsykinesia
antipsychotics, metoclopramide
48
Musculo/Skin/Connective Tissue: name 2 agents take can cause fat redistribution
protease inhibitors, glucocorticoids (Fat PiG)
49
M/S/C: name 4 drugs that can cause gingival hyperplasia
phenytoin, verpamil, cyclosporine, nifedipine
50
M/S/C: name 5 drugs that can cause hyperuricemia (gout)
Painful Tophi and Feet Need Care
| Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
51
M/S/C: 8 drugs that can cause myopathy
fibrates, niacin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids
52
M/S/C: 3 drugs that can cause osteoporosis
corticosteroids, heparin
53
M/S/C: name 4 drugs that can cause photosensitivity
SAT For Photo
| Sulfonamides, Amiodarone, Tetracyclines, 5-FU
54
M/S/C: name 9 rugs that can cause rash Steven-Johnson Syndrome
Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin
anti-epileptic drugs (ethosuximide, carbamezapine, lamotrigine, phenytoin, phenobarbital) Allopurinol, Sulfa drugs, Penicillin
55
M/S/C: 6 drugs that can cause SLE-like syndrome
having lupus is SHIPP-E
| sulfa drugs, hydrazaline, INH, Procainamide, Phenytoin, Etanercept
56
M/S/C: drug that causes teeth discoloration
tetracycline
57
M/S/C: drug that can lead to tendonitis, tendon rupture, and cartilage damage
fluoroquinolones
58
renal/GI: name 2 drugs that can diabetes insipidus
lithiiium, demeclocyline
59
renal/GI: name 1 drug that can cause Fanconi syndrome
expired tetracycline
60
renal/GI: name 2 drugs that can cause hemorrhagic cystitis, how to you prevent it?
cyclophosphamide, and ifosfamide. give mensa
61
renal/GI: name 3 drugs that cause interstitial nephritis
methicillin, NSAIDs, furoseminde
62
renal/GI: 3 drugs that cause SIADH
can't concentration serum sodium
| Carbamezepine, Cyclophosphamide, SSRIs
63
pul: 1 drug that causes dry cough
ACE inhbitors
64
pul: 4 drugs that cause pulmonary fibrosis
breathing air badly form medications
| bleomycin, amiodarone, busulfan, methotrexate
65
multiorgan: name 4 drugs that cause antimuscarinic
atropine, TCAs, H1-blockers, antipsychotics
66
multiorgan: 5 drugs that can cause disulfarin-like reaction
metronidazole, certain cephalopsorins, griseofulvin, procarbazine, 1st line sulfonyureas
67
multiorgran: 4 drugs that cause nephrotoxicity/otoxicity
aminoglycosides, vancomyocin, loop diuretics, cisplatin
68
P-450 inducers
chronic alcohol abuse, modafinil, St.John's wort, phenytoin, phenobarbital, nevirapine, rifampin, griseofulvin, carabamazepine. Chronic alcholic Mona Steals Phen-Phen and Never Refuses Greasy, Carbs.
69
P-450 Substrates
anti-epileptics, antidepressants, antipsychotics, anesthetics, theophyliine, warfain, statins, OCPs
Always, Always, Always, Always, Think When Starting Overs
70
P-450 inhibitors
acute alcohol abuse, gemfibrozil, ciprofloxacin, isoniazid, grapefruit juice, quinidine, amiodarone, ketoconazole, macrolides, sulfonamides, cimetidine, ritonavir,
A cute Gentleman "Cipped" Iced grapefruit juice quickly And Kept Munching On Soft Cinammon Rolls
71
Name 8 sulfa drugs
Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas Popular FACTSSS
72
pts with sulfa allergies may develop 7 symptoms (severity of symptoms)
fever, urinary tract infection, Steven-Johnson Syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)
range from mild to life threatening
