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Master PA Deck > Pharm GERD IBD Motility > Flashcards

Pharm GERD IBD Motility Flashcards

(66 cards)

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1
Q

Hydrocortisone

A

Topical corticosteriod or enema

IBD management

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2
Q

Budesonide

A

Topical foam or oral corticosteroid

IBD management

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3
Q

Prednisone

A

Oral corticosteriod

IBD management

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4
Q

Sulfasalazine

A

Class: Aminosalicylate

IBD Management

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5
Q

Mesalamine

A

Class: Aminosalicylate

IBD Management

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6
Q

Olsalazine

A

Class: Aminosalicylate

IBD management

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7
Q

Balsalazide

A

Class: Aminosalicylate

IBD management

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8
Q

IBD Management Sequence

A 
Aminosalicylates
Corticosteriods
Immunomodulators
TNF alpha inhibitors
Antibiotics
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9
Q

Immunomodulators for IBD

A

Azathioprine
Mercaptopurine
Cyclosporine
Methotrexate

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10
Q

Sodium Bicarbonate

A

Antacid

GERD Management

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11
Q

Calcium Carbonate

A

Antacid

GERD Management

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12
Q

Magnesium hydroxide + Aluminum hydroxide

A

Antacid

GERD Management

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13
Q

Cimetidine

A

H2 Blocker

GERD Management

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14
Q

Famotidine

A

H2 Blocker

GERD Management

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15
Q

Ranitidine

A

H2 Blocker

GERD Management

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16
Q

Nizatidine

A

H2 Blocker

GERD Management

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17
Q

Omeprazole

A

PPI

GERD Management (1x day)
PUD/H. Pylori (Multiple times a day)
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18
Q

Esomeprazole

A

PPI

GERD Management (1x day)
PUD/H. Pylori (Multiple times a day)
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19
Q

Pantoprazole

A

PPI

GERD Management (1x day)
PUD/H. Pylori (Multiple times a day)
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20
Q

Lansoprazole

A

PPI

GERD Management (1x day)
PUD/H. Pylori (Multiple times a day)
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21
Q

Dexlansoprazole

A

PPI

GERD Management (1x day)
PUD/H. Pylori (Multiple times a day)
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22
Q

Rabeprazole

A

PPI

GERD Management (1x day)
PUD/H. Pylori (Multiple times a day)
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23
Q

Misoprostol

A

Analogue of PGE, stimulates secretion of mucus and bicarbonate

GERD Management of patients on NSAIDs

Contraindicated in pregnancy

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24
Q

Sucralafate

A

Salt of sucrose complexed to aluminum hydroxide which forms viscous paste that binds selectively on ulcers or erosions

GERD Management

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25
Triple therapy
H. Pylori Management High dose PPI plus Antibiotics (Clarithromycin and [Amoxicillin or Metronidazole])
26
Prevpac
Triple therapy combination product for H. Pylori Lansoprazole, amoxicillin, clarithromycin
27
Pylera
Triple therapy combination product for H. Pylori Bismuth subcitrate potassium, metronidazole, tetracycline
28
Quadruple Therapy
H. Pylori management High dose PPI plus Bismuth subsalicylate plus Metronidazole and [tetracycline or doxycycline]
29
Bethanechol
Cholinomimetic agent (stimulates muscarinic receptors and increases smooth muscle tone) Motility Disorders
30
Neostigmine
``` Cholinomimetic agent (Acetylcholinesterase inhibitor and blocks destruction of ACh) ``` Motility Disorders
31
Metoclopramide
D2 receptor blocker Requires renal adjustment Motility Disorders
32
Domperidone
D2 receptor blocker NOT FDA approved Motility Disorders
33
Erythromycin
Macrolides (antibiotic) Motility Disorders
34
Erythromycin (side effects)
- QTc prolongation, ventricular arrhythmias - Abdominal pain/cramping, diarrhea - Decreased efficacy with long term use (4+ weeks)
35
Erythromycin (Drug interactions)
Numerous, major CYP3A4 inhibitor
36
Macrolides (MOA)
- Mimics motilin, a potent contractile agent | - Cholinergic facilitation
37
Domperidone (Side effects)
- QTc prolongation, cardiac arrest | - Abdominal cramps
38
Domperidone (Drug interactions)
- CYP3A4 inhibitors | - QTc prolonging medications
39
Metoclopramide (Side effects)
Drowsiness, dystonic reaction, restlessness, bronchospasms, prolactin elevation
40
Metoclopramide (Drug interactions)
Antipsychotic agents Atovaquone (antimalarial) Droperidol
41
D2 Receptor Blockers (MOA)
Blockade of D2 receptors which leads to increased smooth muscle stimulation - increased esophageal peristalsis - increased lower esophageal sphincter pressure - increased gastric emptying
42
D2 Receptor Blockers
*Common for diabetic gastroparesis* Metoclopramide Domperidone
43
Neostigmine (Drug Interactions)
Beta blockers Corticosteroids Succinylcholine
44
Neostigmine (Side Effects)
AV block, bradycardia Dizziness Diaphoresis Bronchospasms
45
Bethanechol (Side Effects)
Abdominal pain, diarrhea Urinary urgency Asthma, bronchoconstriction Flushing, headache, bradycardia
46
Bethanechol (Drug interactions)
Acetylcholinesterase inhibitors | Beta blockers
47
Misoprostol (Side Effects)
Diarrhea, abdominal pain | Detrimental to pregnancy
48
Misoprostol (Drug Interactions)
Antacids, magnesium containing
49
Sucralafate (Side Effects)
Constipation, aluminum toxicity (CKD patients)
50
Sucralafate (Drug Interactions)
Binds to multiple medications
51
PPIs (MOA)
Travel systemically to form irreversible disulfide bonds with proton pumps inactivating them Taken on empty stomach
52
PPIs (Side Effects)
- Decreased B12, Ca and magnesium absorption - Increased risk of bone fractures - Increased risk of C. diff and pneumonia - Increased risk of dementia and CKD - Rebound acid hypersecretion with discontinuation
53
PPIs (Drug Interactions)
Drugs process via CYP2C19 Clopidogrel (Plavix): decreased antiplatelet activity
54
H2 Blockers (MOA)
Acid inhibition via reversible H2 receptor blockade on parietal cells
55
H2 Blockers (Side Effects)
Diarrhea, headache, fatigue, constipation, CNS effects (confusion, hallucinations, delirium) Gynecomastia/impotence (cimetidine only)
56
H2 Blockers (Drug interactions)
Cimetidine (CYP2C9, CYP2D6, CYP1A2, CYP3A4 inhibitor)
57
Antacids (MOA)
Neutralize gastric acid by reacting with HCl
58
Sodium bicarbonate (Side effects)
Belching, metabolic alkalosis, fluid retention
59
Calcium carbonate (Side effects)
Belching, hypercalcemia, metabolic alkalosis
60
Magnesium hydroxide + Aluminum hydroxide (Side effects)
Diarrhea, constipation, aluminum accumulation in CKD
61
Sodium bicarbonate (Drug Interactions)
Elvitegravir (v) Amphetamines (^) Calcium-containing dairy products (v)
62
Calcium carbonate and Magnesium hydroxide + Aluminum hydroxide (Drug interactions)
``` Tetracyclines (v) Fluoroquinolones (v) Itraconazole (v) Iron (v) Calcium-containing dairy (^) Elvitegravir (v) ```
63
TNF alpha inhibitors
Adalimumab Infliximab Golimumab (ulcerative colitis only) Certolizumab (Crohn's only)
64
TNF alpha inhibitors (side effects)
Infections, injection site reactions, headache, nausea, hepatotoxicity
65
Immunomodulators
Azathioprine Mercaptopurine Methotrexate
66
Immunomodulators (side effects)
NVD, myelosuppression, hepatotoxicity | alopecia, photosensitivity, mucositis with methotrexate

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