BS: Inflammation

Question 1

Arachidonic acid products (Vasodilation)

Answer 1

Prostaglandins (PGI2, PGE1, PGE2, and PGD2)

Question 2

Arachidonic acid products (Vasoconstriction)

Answer 2

Thromboxane A2, Leukotrienes C4, D4, and E4

Question 3

Arachidonic acid products (Increased vascular permeability)

Answer 3

Leukotrienes C4, D4, and E4

Question 4

Arachidonic acid products (chemotaxis, leukocyte adhesion)

Answer 4

Leukotrienes B4, Hydroxyelcosatetraenoic acid (HETE)

Question 5

Histamine (source)

Answer 5

mast cells, basophils, platelets

Question 6

Histamine (action)

Answer 6

vasodilation, increased vascular permeability, endothelial activation
important in acute inflammatory response

Question 7

Prostaglandins (source)

Answer 7

mast cells, leukocytes

Question 8

Prostaglandins (action)

Answer 8

vasodilation, pain, fever

important in acute inflammatory response

Question 9

Leukotrienes (source)

Answer 9

mast cells, leukocytes

Question 10

Leukotrienes (action)

Answer 10

Increased vascular permeability, chemotaxis, leukocyte adhesion, and activation
important in acute inflammatory response

Question 11

Chemokines (source)

Answer 11

Leukocytes, activated macrophages, endothelial cells, T-lymphocytes, mast cells

Question 12

Chemokines (action)

Answer 12

Chemotaxis, leukocyte activation; recruitment of leukocytes to site of activation, migration of cells in normal tissues

Question 13

Platelet-activating factor (source)

Answer 13

Leukocytes, mast cells

Question 14

Platelet-activating factor (action)

Answer 14

Vasodilation, increased vascular permeability, leukocyte adhesion, chemotaxis, degranulation, oxidative burst

Question 15

Complement (source)

Answer 15

plasma (produced in liver)

Question 16

Complement (action)

Answer 16

Leukocyte chemotaxis and activation, direct target killing (membrane attack complex), vasodilation (mast cell stimulation)

Question 17

Kinins (source)

Answer 17

plasma (produced in liver)

Question 18

TNF (source)

Answer 18

macrophages, mast cells, T-lymphocytes

Question 19

TNF (action)

Answer 19

acute inflammation

stimulates expression of endothelial adhesion molecules and secretion of other cytokines; systemic effects

Question 20

IL-1 (source)

Answer 20

macrophages, endothelial cells and some epithelial cells

Question 21

IL-1 (action)

Answer 21

acute inflammation
stimulates expression of endothelial adhesion molecules and secretion of cytokines; large role in the production of fever

Question 22

IL-6 (source)

Answer 22

Macrophages, other cells

Question 23

IL-6 (action)

Answer 23

acute inflammation

systemic effects

Question 24

IL-17 (source)

Answer 24

T Lymphocytes

Question 25

IL-17 (action)

Answer 25

*acute inflammation* | recruitment of neutrophils and monocytes

Question 26

IL-12 (source)

Answer 26

dendritic cells, macrophages

Question 27

IL-12 (action)

Answer 27

*chronic inflammation* | increased production of IFN-Y

Question 28

IFN-Y (source)

Answer 28

T lymphocytes, NK cells

Question 29

IFN-Y (action)

Answer 29

*chronic inflammation* | activation of macrophages (increased ability to kill microbes and tumor cells)

Question 30

IL-17 (source)

Answer 30

T lymphocytes

Question 31

IL-17 (action)

Answer 31

*chronic inflammation* | recruitment of neutrophils and monocytes

Question 32

Chronic Inflammation Cytokines

Answer 32

IL-12, IFN-Y, IL-17

Question 33

Acute Inflammation Cytokines

Answer 33

TNF, IL-1, IL-6, IL-17 and chemokines