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Master PA Deck > BS: Hypersensitivity > Flashcards

BS: Hypersensitivity Flashcards

(73 cards)

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1
Q

Allergic rhinitis, sinusitis (Rx type)

A

Type I Immediate Hypersensitivity

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2
Q

Allergic rhinitis, sinusitis (manifestation)

A

Increased mucous secretion, inflammation of upper airways and sinuses

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3
Q

Food Allergies (Rx type)

A

Type I Immediate Hypersensitivity

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4
Q

Food Allergies (manifestation)

A

Increased peristalsis due to contraction of intestinal muscles

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5
Q

Bronchial Asthma (Rx type)

A

Type I Immediate Hypersensitivity

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6
Q

Bronchial Asthma (manifestation)

A

Airway Obstruction caused by bronchial smooth muscle hyperactivity, inflammation and tissue injury in late phase

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7
Q

Anaphylaxis (Rx type)

A

Type I Immediate Hypersensitivity

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8
Q

Anaphylaxis (manifestation)

A

Hypotension caused by vasodilation, airway obstruction due to bronchoconstriction and laryngeal edema

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9
Q

Autoimmune hemolytic anemia (Rx type)

A

Type II: Antibody-mediated hypersensitivity

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10
Q

Autoimmune hemolytic anemia (target antigen)

A

erythrocyte membrane proteins (Rh blood group antigens, I antigens)

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11
Q

Autoimmune hemolytic anemia (mechanism)

A

opsonization and phagocytosis of erythrocytes

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12
Q

Autoimmune hemolytic anemia (manifestation)

A

Hemolysis, anemia

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13
Q

Autoimmune (idiopathic) thrombocytopenic purpura (Rx type)

A

Type II: Antibody Mediated Hypersensitivity

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14
Q

Autoimmune (idiopathic) thrombocytopenic purpura (Target antigen)

A

platelet membrane proteins

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15
Q

Autoimmune (idiopathic) thrombocytopenic purpura (mechanism)

A

Opsonization and phagocytosis of platelets

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16
Q

Autoimmune (idiopathic) thrombocytopenic purpura (manifestation)

A

Bleeding

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17
Q

Goodpasture Syndrome (Rx type)

A

Type II: Antibody Mediated Hypersensitivity

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18
Q

Goodpasture Syndrome (Target antigen)

A

noncollagenous protein in basement membrane of kidney glomeruli and lung aveoli

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19
Q

Goodpasture Syndrome (mechanism)

A

Complement and Fc receptor- mediated inflammation

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20
Q

Goodpasture Syndrome (manifestation)

A

Nephritis, lung hemorrhage

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21
Q

Graves disease “hyperthyroidism” (Rx type)

A

Type II: Antibody Mediated Hypersensitivity

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22
Q

Graves disease “hyperthyroidism” (target antigen)

A

Thyroid stimulating hormone (TSH) receptor

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23
Q

Graves disease “hyperthyroidism” (mechanism)

A

Antibody-mediated stimulation of TSH receptors

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24
Q

Graves disease “hyperthyroidism” (manifestation)

A

Hyperthyroidism

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25
Myasthenia gravis (Rx type)
Type II: Antibody-mediated hypersensitivity
26
Myasthenia gravis (target antigen)
acetylcholine receptor
27
Myasthenia gravis (mechanism)
antibody inhibits acetylcholine binding, down-modulates receptors
28
Myasthenia gravis (manifestation)
muscle weakness, paralysis
29
Pemphigus vulgaris (Rx type)
Type II: Antibody-mediated hypersensitivity
30
Pemphigus vulgaris (target antigen)
proteins in intercellular junctions of epidermal cells
31
Pemphigus vulgaris (mechanism)
antibody-mediated activation of proteases, disruption of intercellular adhesions
32
Pemphigus vulgaris (manifestation)
skin vesicles (bullae)
33
Pernicious anemia (Rx type)
Type II: Antibody-mediated hypersensitivity
34
Pernicious anemia (target antigen)
intrinsic factor of gastric parietal cells
35
Pernicious anemia (mechanism)
neutralization of intrinsic factor, decreased absorption of vitamin B12
36
Pernicious anemia (manifestation)
abnormal erythropoiesis, anemia
37
Rheumatic fever (Rx type)
Type II: Antibody-mediated hypersensitivity
38
Rheumatic fever (target antigen)
Streptococcal cell wall antigen; antibody cross-reacts with myocardial antigen
39
Rheumatic fever (mechanism)
inflammation, macrophage activation
40
Rheumatic fever (manifestation)
myocarditis, arthritis
41
Systemic lupus erythematosus (Rx type)
Type III: Immune complex hypersensitivity
42
Systemic lupus erythematosus (antibody specificity)
DNA, nucleoproteins
43
Systemic lupus erythematosus (manifestations)
Nephritis, arthritis, vasculitis
44
Polyarteritis nodosa (Rx type)
Type III: Immune complex hypersensitivity
45
Polyarteritis nodosa (antibody specificity)
Mostly unknown, sometimes microbial antigens
46
Polyarteritis nodosa (manifestation)
Vasculitis
47
Poststreptococcal glomerulonephritis (Rx type)
Type III: Immune Complex Hypersensitvity
48
Poststreptococcal glomerulonephritis (Antibody specificity)
Streptococcal cell wall antigens
49
Poststreptococcal glomerulonephritis (manifestation)
Nephritis
50
Multiple sclerosis (Rx type)
Type IV: T-Cell Mediated Hypersensitivity
51
Multiple sclerosis (Specificity of pathogenic T cells)
Myelin proteins
52
Multiple sclerosis (manifestation)
Demyelination in the CNS, sensory and motor dysfunction
53
Rheumatoid arthritis (Rx type)
Type IV: T-Cell Mediated Hypersensitivity
54
Rheumatoid arthritis (Specificity of pathogenic T cells)
Unknown antigens in joint
55
Rheumatoid arthritis (manifestation)
Inflammation of synovium and erosion of cartilage and bone in joints
56
Type 1 Diabetes (Rx type)
Type IV: T-Cell Mediated Hypersensitivity
57
Type 1 Diabetes (Specificity of pathogenic T cells)
Pancreatic islet antigens
58
Type 1 Diabetes (manifestations)
Impaired glucose metabolism, vascular disease
59
Crohn's Disease (Rx type)
Type IV: T-Cell Mediated Hypersensitivity
60
Crohn's Disease (Specificity of pathogenic T cells)
Unknown, possibly intestinal microbes
61
Crohn's Disease (Manifestation)
inflammation of the bowel wall; abdominal pain, diarrhea, hemorrhage
62
Contact sensitivity (Rx type)
Type IV: T-cell Mediated Hypersensitivity
63
Contact sensitivity (Specificity of pathogenic T cells)
Modified skin proteins
64
Contact sensitivity (Manifestation)
DTH reaction in skin, rash
65
Chronic infections i.e. TB (Rxt type)
Type IV: T-cell Mediated Hypersensitivity
66
Chronic infections i.e. TB (Specificity of pathogenic T cells)
Microbial proteins
67
Chronic infections i.e. TB (manifestation)
Chronic inflammation
68
Viral hepatitis (Rx type)
Type IV: T-cell Mediated Hypersensitivity
69
Viral hepatitis (Specificity of pathogenic T cells)
virally encoded proteins
70
Viral hepatitis (manifestation)
CTL-mediated hepatocyte death; liver dysfunction; fibrosis
71
Super antigen-mediated diseases i.e. toxic shock syndrome
Type IV: T-cell Mediated Hypersensitivity
72
Superantigen-mediated diseases i.e. toxic shock syndrome (Specificity of pathogenic T cells)
Polyclonal (microbial superantigens activate many T cells of different specificities
73
Super antigen-mediated diseases i.e. toxic shock syndrome (manifestation)
Fever, shock related to systemic inflammatory cytokine release

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