Pharm TT3 Flashcards Preview

Pharm TT3 > Pharm TT3 > Flashcards

Flashcards in Pharm TT3 Deck (230)
Loading flashcards...
1

Bacteria with natural resistance

P aeruginosa

2

Resistance mechanism for streptococcus and quinolone

Modification to existing target

3

Resistance MOA for MERSA and cloxacillin

Acquisition of a target bypass system
- change binding site so methicillin and cloxacillin don’t work

4

Resistance MOA of P aeruginosa

Reduce cell permeability in porin
- resistant to imipenem

5

Resistance MOA for streptococcus tetracycline

Efflux pump

6

G+ bacteria, non-resistant that we have to know

MSSA
S viridans
S pneumoniae
Enterococcus

7

G+ resistant bacteria that we have to know (2)

MRSA
MRSA-c

8

G-, non-resistant that we have to know (3)

E. coli
Klebsiella
H influenze

9

G- resistant that we have to know (4)

E. coli ESBL
Klebsella ESBL
Pseudomonas
Enterobacter

10

Anaerobes bacteria we have to know, non-resistant (2)

Actinomycetes
Peptostreptoccus

11

Anaerobes resistant (1)

Bacteriode

12

Atypical non-resistant

Pycoplasma
Chlamydia
Legionella

13

Penicillin properties (MOA, target, absorption, elim, ADR)

Inhibit transpeptidase
Only for strep infection
Anti-staph penicillin = cloxacillin
Mod to poor absorption and liable to acid secretion; renal elim
ADR: interstitial nephritis
Not for G-
Cloxacillin is DOC for MSSA and strep aureus (PO or IV)

14

Piperacillin

Biggest penicillin
Beta lactamases can’t cleave

15

Cephalosporin properties

Same as penicillin except with 2 R groups
Dihydrothiazine
R3 changes PK, R7 changes spectrum
ADR: IgE hypersensitivity, anaphylaxis, C diff, cross sensitivity, interstitial nephritis

16

Cefazolin

Cephalosporin
1st gen
Treat only S aureus and streptococci
Good for MSSA

17

Ceftriaxone

Biggest cephalosporin
For difficult infections like pseudomonas and S pneumoniae
Does strep really well

18

Mycoplasma pneumoniae

No cell well
Nothing that targets cell wall works
(Penicillin and cephalosporin)

19

Peptostretococcus

Part of oropharyngeal flora and easily killed by cephalosporin

20

How to treat MRSA

Vancomycin

21

Does MSSA make beta lactamases

Yes
15% need vancomycin
85% can tx with cephalosporin

22

Clavulanic acid plus

Ampicillin or ticarcillin

23

Tazobactam plus

Pipercillin or ceftolozane

24

Carbapenems (drugs

Imipenem, cilastatin, meropenem
Meropenem not affect by meta lactamases
Good for G-/G+/ESBL and pseudomonas and bacteroids

25

Vancomycin

Doesn’t allow for crosslink to happen
DOC for MRSA, and enterococcus
Resistance for VRE
ADR hearing loss and nephrotoxicity and red man syndrome (histamine release)

26

Daptomycin

Cyclic lipopeptide
Mess up K channel
For MRSA and enterococcus
DI: surfactant antagonize the action
- not for pneumonia
ADR: myopathy, creatine phosphokinase increase

27

Treatment for C diff

Vancomycin

28

Drugs causing C diff the most

Clindamycin
Fluoroquinolones

29

Thrush symptoms

Typically asymptomatic
Burning oral sensation, change in taste, tendency to bleed
Erythematous: smooth red patch on mucosal area

30

Thrush risk factor

Prolonged illness, use of Ab, use of steroid, denture, dry mouth