Pharmacodynamics

Question 1

Pharmacodynamics

Answer 1

What the drug does to the body

Question 2

Quantal dose response curve

Answer 2

ED50, threshold dose (steep curve, little variability)

Magnitude of response is graded so more dose means more effect

Question 3

Agonist vs antagonist

Answer 3

Agonist: drug that binds receptors to elicit a response
Antagonist: bind receptors but do not elicit response

Question 4

Drug development process

Answer 4

Discovery and characterization of drug
Preclinical trials (acute subacute and chronic toxicity must be tested on 2 animas, pharmacological profile, carcinogenesis,etct)
IND application
Clinical studies
Submission of NDA
Approval of NDA
Postmarketing surveillance