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Flashcards in Pharmacology Deck (61)
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1

Pharmacodynamics is...

What a drug does to the body

2

Pharmacokinectics is...

What a body does to the drug (absorption, distribution, eliminations etc.)

3

Efficacy is...

They ability of an agonist to evoke a response
Higher efficacy = larger response

4

Affinity is...

The strength of association between agonist and its receptor
Greater affinity = greater duration of binding

5

EC50 is...

The concn of agonist that results in a half maximal response (i.e. 50% of receptors are occupied)

6

Agonist A requires 0.01 concn to elicit a response.
Agonist B requires 0.05 concn to elicit a response.
Agonist A is more ____ than agonist B.

Potent

7

In the presence of a competitive antagonist, EC50 is unchanged. True/False?

False
EC50 increases (need to increase concn of agonist to get response)

8

Both the ionised and unionised form of a drug readily diffuse across the lipid bilayer. True/False?

False
Only the unionised form does

9

pKa is...

The pH at which 50% of a drug is ionised and 50% is unionised

10

Henderson Hasselbach Equation

pH = pKa + log[A-]/[HA]
pKa - pH = log[HA]/[A-]
FOR WEAK ACIDS ONLY

11

Increasing the pH of an acidic drug causes it to become less ionised. True/False?

False
It becomes more ionised (acid drugs are less ionised in an acid environment)

12

Administration routes that by-pass first pass metabolism are...

Sublingual, rectal

13

Vd = volume of distribution = ?

Volume in which a drug is dissolved
Dose given/Plasma Concn

14

Vd less than 5L suggests...

Drug is contained in vascular compartment

15

Vd less than 15L suggests...

Drug is restricted to extracellular water

16

Vd greater than 15L suggests...

Drug is in total body water

17

Efferent signals travel _________ the CNS

Away from

18

Sympathetic preganglionic NT is?

Acetylcholine (cholinergic)

19

Sympathetic postganglionic NT is?

Noradrenline (adrenergic)

20

Parasympathetic pre and post ganglionic NT is acetylcholine. True/False?

True

21

Sympathetic outflow is craniosacral. True/False?

False
Thoracolumbar (T1-L2)

22

Preganglionic neurone of sympathetic chain is long. True/False?

False
Short - preganglionic neurone of parasympathetic chain is long as ganglions are usually embedded in the target organ

23

Location of cranial parasympathetic ganglia in the head and neck

C3, C7, C9, C10

24

Parasympathetic stimulation decreases force of heart contraction. True/False?

False
Has no effect on force of contraction, but does decrease heart rate

25

Components of a G-protein

α (contains guanine nucleotide binding site)
β + γ complex

26

GP couples with receptor to increase affinity for GDP. True/False?

False
Affinity for GDP decreases and it eventually dissociates, increasing affinity for GTP to bind on α subunit

27

M1 G-protein coupled receptor is G_
Causes ___ acid secretion in stomach

q
Increased

28

M2 G-protein coupled receptor is G_
Causes ___ heart rate

i
Decreased

29

M3 G-protein coupled receptor is G_
Causes ___ of airways; ___ of vasculature

q
Contraction, relaxation

30

ACh and NA can be broken down in the synaptic cleft if not taken up by the effector cell. True/False?

False
NA is not broken down in the cleft - U1 and U2 are involved