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Flashcards in Pharmacology Deck (24)
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1

what innervates skeletal muscle?

motoneurones

2

motoneuroens are myelinated true/false

truethey have myelinated axons and cell bodies in the spinal cord 

3

when nearing the muscle the motor neurone axon does what?

divides into unmyelinated branches

4

branhces further divide into fine branches before enidng with what?

terminal bouton 

5

the terminal bouton forms what with the muscle membrane?

a chemical synpase at the neuromuscular junction 

6

action potentials arising in the cell body are conducted via the ____ to the _____ _____

axon 

terminal boutons

7

what is released following conduction of an action potential? 

ACh

8

where specifically on the muscle fibre does the presynaptic terminal (bouton) synapse?

endplate region of the skeletal muscle fibre

9

what are the four key structural features of the neuromuscular junction? 

terminal bouton 

synaptic vesicles

synaptic cleft

end plate region of muscle cell mebrane 

10

which cells of the PNS surround the terminal bouton?

Schwann cells

11

synaptic vesicles contain what?

ACh

12

what is the name given to the area where synaptic vesicles cluster awaiting release of their ACh?

active zones

13

nicotonic ACh receptors are located where?

junctional folds that face the active zones

14

what are the five steps of synaptic transmission at the neuromuscluar junction?

1. Synthesis

2. Storage 

3. Release

4. Receptor activation 

5. Transmitter activation 

15

ACh is synthesised in the cytosol from what?

choline and acetyl coenzyme A 

16

what supplies the acetyl CoA used in the synthesis of ACh?

mitochondria

17

what enzyme synthesises ACh?

choline acetyltransferase (CAT)

18

what is the function of vesicular ACH transporters?

to concentate ACh in vesicles

 

19

arrival of an action potential at eh terminal casues what?

depolarisation and opening of voltage actived Ca2+ channles allowing Ca2+ entry to terminal 

20

what does the presence of Ca2+ cause at the terminal?

vesicles at active zones fuse with the presynaptic membrane and ACh diffuses into the synaptic cleft

21

ACh in the synaptic cleft activates what?

post synaptic nicotonic ACh receptors in the endplate region 

22

how are nicotonic ACh receptors assembled?

pentamer of glycoprotein subunits surrounding central cation selective pore (formed from five M2 helices)

23

the influx of Na2+ is greater than the efflux of K+ through the gate in the nicotonic ACh receptor true/false?

true

24

what is the name of the depolarisation