Pharmacology - Test 2 - Drug Addiction Flashcards Preview

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Flashcards in Pharmacology - Test 2 - Drug Addiction Deck (19):
1

What is it?

brain disorder, chronic, powerful, treatable

2

loss of control

seeking/taking in spite of consequence

3

how is is studied

animals, biological basis, inate hunger

4

how do they work?

affect neural communication

5

cocaine

binds to transporter, blocks reuptake, increases dopamine [ ] = REWARD.

6

dopamine receptors

G protein coupled (GPCR), gene expression

7

how do drugs change gene expression

signal transduction, mRNA levels, proteins

8

epigenetics

DNA related changes in gene expression, no mutations

9

two mechanisms of epigenetics

1) methylation= prevents translation. 2) acetylation of histone -->opening of chromatin = translation

10

Why are they responsive to medications?

physiological basis

11

medication for PS abusers (anyone know what that is?) Prohibited substance?

None approved. focus on dopamine. block euphoria, reduce withdrawal, lessen craving, enhance impaired corticol function. RTI-336, vaccine tx

12

How can we visual brain function?

brain imaging

13

how long can it take the brain to return to normal?

months to years

14

Why are drug so powerful?

override removal mechanisms, alter signal transduction (insert photo: mice having sex)

15

what regulates natural and biological rewards?

mesocorticolimbic pathway (feeding, drinking, love and sex)

16

cocaine in squirrel monkeys

major increase in basal dopamine

17

Drugs harness?

our strongest instincts and survival drives. Target powerful endogenous reward

18

takeaway

drug taking innate drive, affects neurotransmission, alter gene expression, the brain cannot control DRUGS!!, long lasting effects, chronic/relapsing, DA,

19

How do drugs control behavior?

affect brain systems designed to ensure survival of the species.