Flashcards in Pharmacology - Test 2 - Drug Addiction Deck (19):
What is it?
brain disorder, chronic, powerful, treatable
loss of control
seeking/taking in spite of consequence
how is is studied
animals, biological basis, inate hunger
how do they work?
affect neural communication
binds to transporter, blocks reuptake, increases dopamine [ ] = REWARD.
G protein coupled (GPCR), gene expression
how do drugs change gene expression
signal transduction, mRNA levels, proteins
DNA related changes in gene expression, no mutations
two mechanisms of epigenetics
1) methylation= prevents translation. 2) acetylation of histone -->opening of chromatin = translation
Why are they responsive to medications?
medication for PS abusers (anyone know what that is?) Prohibited substance?
None approved. focus on dopamine. block euphoria, reduce withdrawal, lessen craving, enhance impaired corticol function. RTI-336, vaccine tx
How can we visual brain function?
how long can it take the brain to return to normal?
months to years
Why are drug so powerful?
override removal mechanisms, alter signal transduction (insert photo: mice having sex)
what regulates natural and biological rewards?
mesocorticolimbic pathway (feeding, drinking, love and sex)
cocaine in squirrel monkeys
major increase in basal dopamine
our strongest instincts and survival drives. Target powerful endogenous reward
drug taking innate drive, affects neurotransmission, alter gene expression, the brain cannot control DRUGS!!, long lasting effects, chronic/relapsing, DA,