phase 2 haem

Question 1

If someone had folate and B12 deficiency what do u correct first

Answer 1

b12

Question 2

why does vitamin b12 cause sensory issues

Answer 2

can result in subacute combined degeneration of the spinal cord.

Can present with sensory deficits, paraesthesia, weakness, ataxia and gait disturbance

Question 3

when do sickle cell symptoms begin

Answer 3

a few minths old

Question 4

secodary causes of polycthaemia

Answer 4

Alcohol
Chronic hypoxia
Obstructive sleep apnoea
Living at altitude
Lung disease affecting oxygen transfer
Smoking
EPO secreting tumours

Question 5

what is Haemolytic uraemic syndrome

Answer 5

triad of microangiopathic haemolytic anaemia, thrombocytopenia and renal impairment.

Most are diarrhoea-associated (caused by Shiga-toxin producing E.coli) in children

Question 6

mild malaria treatment

Answer 6

oral (hydroxy)chloroquine

Question 7

sevrre malaria treatment

Answer 7

IV artesunate.

Question 8

management for hereditary spherocytosis?

Answer 8

Splenectomy

Question 9

is alpha thalassemia compatible with life

Answer 9

yes unless u have the 4 gene deletion subgroup

Question 10

signs or symptoms of immune thrombocytopenia purpura.

Answer 10

Easy bruising, epistaxis, menorrhagia, purpura, gum bleeding

Question 11

Which chromosomal abnormalities are associated with multiple myeloma?

Answer 11

t (11;14)

Question 12

what cancer can cause gum hypertrophy

Answer 12

acute myelod lekauemia

Question 13

What 2 things are associated with AML

Answer 13

DOWNS SYNDRMOME
RADIATION

Question 14

AML treatment

Answer 14

Blood transfusion
Allopurinol (to prevent tumour lysis)
IV antibiotics
Chemotherapy
Steroids
Bone marrow transplant

Question 15

clinical examination of patient witg CLL

Answer 15

Enlarged, rubbery, non-tender lymph nodes
Sweating, anorexia
Commonly asymptomatic

Question 16

tretament of CLL

Answer 16

Chemotherapy
Monoclonal antibodies (rituximab)
Bruton tyrosinekinase inhibitors (ibrutinib)

Question 17

what does chest x ray in hodgkins lymphoma show

Answer 17

wide mediastinum

Question 18

treatment of hodghkins lymphoma

Answer 18

Chemotherapy ABVD treatment
Marrow transplant

Question 19

3 of the common symptoms of G6PD deficiency?

Answer 19

Fatigue, palpitations, shortness of breath, pallor

Question 20

first line test for DVT

Answer 20

D DIMER

if positive do doppler ultrasound

Question 21

4 factots in wels score

Answer 21

clinical signs and symptomsof dvt
previous dvt or pe
heart rate more than 100
no alternative diagbosis

Question 22

what do u give in sepsis 6

Answer 22

: Fluids, Broad spectrum Abx, Administer O2 if required

Question 23

what do u take in sepsis 6

Answer 23

Bloods, Urine Output, Lactate
levels

Question 24

differential diagnosis for polycytheamia vera

Answer 24

Acute dehydration, chronic obesity/HTN/alcohol excess

Question 25

what causes haemophilia c

Answer 25

autosomal recessive
factor xi deficinecy

Question 26

define bleeding time

Answer 26

a laboratory test to assess platelet function and the body’s ability to
form a clot.

Question 27

define prothrombin time

Answer 27

a measure of the integrity of the extrinsic and final common pathways of
the coagulation cascade

Question 28

define APTT

Answer 28

– a measure of the functionality of the intrinsic and common pathways of the coagulation
cascade

Question 29

define thrombin time

Answer 29

Thrombin time is a screening coagulation test designed to assess fibrin formation
from fibrinogen in plasma