Flashcards in PHYS: CO2 Transport and Acid-Base Deck (10):
What are the 3 mechanisms for CO2 transport in the blood?
Dissolved CO2 (5-10%)
Protein carbamylation (10-20%)
Formation of Bicarbonate (80-90%)
What is the rate-limiting step of bicarbonate production?
H2O + CO2 --> H2CO3
True or false: carbonic anhydrase is present in plasma.
FALSE: present in RBCs (CO2 and H2CO3 can diffuse/be transported across surfaces)
How does HCO3- get back into plasma after forming in RBCs?
Hamburger's phenomenon: band 3 protein is an anion exchange protein that takes Cl- (and water) in for every HCO3- out
What happens to H+ ions in RBCs?
buffered by deoxyhemoglobin
What are the main differences between CO2 dissociation and O2 dissociation curves?
CO2 curve is:
-No cooperativity (linear)
What is the Bohr effect?
when H+ binds to hemoglobin (acidosis) it decreases the affinity for oxygen--shifting curve to right and causing oxygen release
pH depends on the ratio of what two values?
HCO3- / Pco2
Hypoventilation causes what respiratory acid/base condition?
acidosis (retention of CO2)