PHYS: CO2 Transport and Acid-Base Flashcards Preview

Pulmonary > PHYS: CO2 Transport and Acid-Base > Flashcards

Flashcards in PHYS: CO2 Transport and Acid-Base Deck (10):
1

What are the 3 mechanisms for CO2 transport in the blood?

Dissolved CO2 (5-10%)
Protein carbamylation (10-20%)
Formation of Bicarbonate (80-90%)

2

What is the rate-limiting step of bicarbonate production?

H2O + CO2 --> H2CO3

3

True or false: carbonic anhydrase is present in plasma.

FALSE: present in RBCs (CO2 and H2CO3 can diffuse/be transported across surfaces)

4

How does HCO3- get back into plasma after forming in RBCs?

Hamburger's phenomenon: band 3 protein is an anion exchange protein that takes Cl- (and water) in for every HCO3- out

5

What happens to H+ ions in RBCs?

buffered by deoxyhemoglobin

6

What are the main differences between CO2 dissociation and O2 dissociation curves?

CO2 curve is:
-Hgiher
-No cooperativity (linear)
-Much steeper

7

What is the Bohr effect?

when H+ binds to hemoglobin (acidosis) it decreases the affinity for oxygen--shifting curve to right and causing oxygen release

8

pH depends on the ratio of what two values?

HCO3- / Pco2

9

Hypoventilation causes what respiratory acid/base condition?

acidosis (retention of CO2)

10

Hyperventilation causes what respiratory acid/base condition?

alkalosis (loss of CO2)