Physiology 1.10 Flashcards Preview

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Flashcards in Physiology 1.10 Deck (13)
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1
Q

What is an excitatory post synaptic potential?

A

change in membrane potential towards an action potential (-50mV); Na+ moves in, K+ moves out

2
Q

What is an inhibitory post synaptic potential?

A

change in membrane potential away from an action potential; Cl- moves in

3
Q

How can an action potential occur if a single excitatory post synaptic potential only generates about 10 mV of change in membrane potential?

A

several synaptic potentials add together to cause an action potential; summation

4
Q

What is temporal summation?

A

1 neuron, many potentials to cause action potential

5
Q

What is spatial summation?

A

more than one neuron being fired to cause action potential

6
Q

What is Lambert Eaton Syndrome?

A

-antibodies to voltage gated Ca2+ channels on presynaptic terminal

7
Q

What is Botulinism Toxin?

A

-destroys SnRPs (NTs not released from synaptic vesicles)

8
Q

What is Myasthenia Gravis?

A

-autoantibodies to the postsynaptic ACh receptors

9
Q

What are the types of ion-gated channels?

A
  • voltage
  • ligand (ionotropic and metabotropic)
  • mechanical
10
Q

What is an ionotropic channel?

A
  • local effects
  • fast response
  • multiple protien subunits
11
Q

What is a metabotropic channel?

A
  • GPCR
  • wide away of effects
  • slow reponse
  • one protein which crosses membrane 7 times
12
Q

Which types of receptors do most anti-cholinergic drugs act on?

A

muscarinic

13
Q

What types of receptors do anesthetic drugs act on?

A

nicotinic