Physiology- Ethanol Flashcards Preview

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Flashcards in Physiology- Ethanol Deck (21):
0

Where does most absorption of ethanol occur?

Small intestine- moves across intestinal wall, picked up by blood stream and distributed everywhere

1

Ethanol absorption when food is present

90% absorbed in one hour
Remaining 10% absorbed in following 30 min

2

Where is ethanol distributed?

All tissues, except adipose, because ethanol is lipophobic

3

Why does ethanol easily cross the blood brain barrier?

Because it is a small molecule

4

How should you modify your weight using a BAC card if you are overweight?

Use ideal weight since ethanol does not absorb into adipose tissue

5

BAC absorption without food present

80% absorbed in 15 min
Remaining 20% absorbed in following 45 min

6

What is the primary enzyme in the liver that breaks down ethanol?

Alcohol dehydrogenase

7

What is ethanol broken down into?

Acetaldehyde (thought to be what causes a hangover)

8

How much ethanol can an average adult male metabolize per hour?

7-10 grams ethanol/hr

9

How can you slow absorption even further?

By eating food with higher fat content

10

What is the difference between how much ethanol is absorbed and how much is metabolized?

BAC

11

What will affect normal absorption or elimination values?

GI or liver pathology, especially having stomach stapled

12

What to know when estimating BAC

Gender
Weight
Drinking history
Eating history
-what was consumed 3 hours before through entire time of drinking

13

Widmark's constant

.68 males
.55 females
Because males typically have higher body water content and females typically have higher % adipose tissue

14

Why is widmarks constant different for males and females?

Because males typically have higher body water content and females typically have higher % adipose tissue

15

Are you impaired if your BAC is below .05?

No

16

How does ethanol act upon nerve cells in CNS?

Increases chloride ion flux into cell, hyperpolarizing it
AKA: CNS depressant

17

Healthy intake of ethanol

20-30g/day (~2 light beers)
There is evidence that moderate intake is beneficial to CV health

18

What are risks of consuming 60-70 g/day?

Increased risk of cancer and stroke

19

What does ethanol do to stomach lining?

Increases acid production in stomach, possibly irritating the lining

20

Chemoreceptors trigger zone (CTZ)

"Vomit center" in the brainstem
-Ethanol stimulates this
-steeper rise of BAC=more CTZ stimulation