Population Genetics Flashcards Preview

biochem 2 > Population Genetics > Flashcards

Flashcards in Population Genetics Deck (20):
1

polymorphic

allele varient that is present in more than 1 percent of the popluation

2

highly polymorphic genes determine what

individual charactersitics

3

nonpolymorphic genes do waht

code for proetins with essential celluarl fucntiosn

4

every human is expected to carry how many deleterious recessive muations

3

5

how many nucleotide polymorphisms are between unrelated humans

6 million

6

what percentage of the world=s polymorphisma re found within any given popluation

90%

7

idea population has what characteriscs

large popluation size
equal fitness of offspring
random mating
no mutation or migration

8

genetic drift

small population

9

why does eugenics not work

the vast majority of mutant alleles are found in heterozygeotes, serving as a large reservoir for the trast
preenting reproduction of heterozygote carriers for recessive diseas will prevent reproduction altoghetr (since we all ahve detrimental alleles)

10

What does CF protect hyterozygotes agaisnt

typhoid fever

11

what population is most affected by CF

uropean

12

what does beta thalassemia protect heterozygotes agaisnt

malaria

13

what population is most affected by beta thalassemia

mediterranean

14

what does HFE protect heterozygotes agaisnt

plague

15

what population is most affected y HFE

european

16

old order amish of lancaster county has high prevalence of what

ellis van creveld

17

french candians have a high prevence of what

tyrosinemia

18

genome wide association studies

millions of SNPs are analyzed to compare the prevalence of certain SNPs in pateints to their prevalence in control cases.

19

linkage

meitoic recombination between the two markers is somewaht unlikely and 2 markers will likely be inherted togeether

20

why are small popluaotions used in studies of gene linkage

only a few genes contribute to disease
little heterogeneity in the disease