Prednisone PO

Question 1

Prednisone and prednisolone Indications

Answer 1

• Bronchospasm associated with asthma or COPD
• Croup
• Minor allergy associated with rash

Question 2

Prednisone and prednisolone contraindications

Answer 2

• Known severe allergy

Question 3

Prednisone and prednisolone cautions

Answer 3

• Age less 5 years with asthma unless they have a clear history and have previously received oral steroids.

Question 4

Prednisone and prednisolone dose, route, and preparation

Answer 4

PO per oral
Adult: 40mg
Child: see paediatric dose table

Question 5

Prednisone and prednisolone mechanism of action

Answer 5

• Is a corticosteroid with with anti-inflammatory and immunosuppressant actions.
• Inhibits production of anti-inflammatory mediators including prostaglandins and leukotrienes
  -prednisone metabolites to prednisolone in liver

Question 6

Prednisone and prednisolone common adverse effects

Answer 6

• Fatigue
• sodium and water retention
• GI reflux