Proteins and enzymes in blood Flashcards Preview

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Flashcards in Proteins and enzymes in blood Deck (15):
1

Most of plasma protein

Albumin
40 g/L
Oncotic pressure, binds things (bili), buffer, aa source.
Reduced in disease: less production, permeable capillaries, more renal and GI loss.

2

CRP

Acute phase protein:
6-8 hours after tissue damage.
Should be

3

Alpha-1-globulin

= alpha-1-antitrypsin
Antagonist to serine proteases.
Positive acute phase protein.

4

Alpha-2-globulins

1. Haptoglobulins
2. Caeruloplasmin - holds copper

5

Beta-globulins

1. Transferrin - transports iron in plasma. Negative acute phase protein.
2. LDL
3. Complements.

6

Gamma-globulins (with concentrations)

IgG 14 g/L
IgA 2.5
IgM 1.5
IgD 0.03
IgE Trace

7

Tumour markers

PSA
AFP - Liver
Ca19-9 - Pancreas
Ca125 - Ovarian
CEA - colorectal

8

Amylase

High in acute pancreatitis

9

Creatinine kinase

Muscle damage
Can be physiologically high in Afrocabs
Pathological:
- Duchenne Muscular Dystrophy
- MI
- Statin myopathy
- Rhabdomyolysis

10

Alkaline Phosphatase

Lots in liver, bone, intestine and placenta.
Physiological rise in pregnancy and childhood.
Pathological rise is bone or liver:
- >5x ULN: Paget's, osteomalacia, cholestasis, cirrhosis
- less: tumours, fractures, osteomyelitis, infiltrated liver, hepatitis.

11

Troponin

Myocardial injury
Measure at 6hr and 12hrs post onset of chest pain.
Stays elevated for a week.

12

Markers of liver cell damage

ALT,
AST,
Alk phos,
gamma GT,
Bilirubin.

13

Aminotransferases (ALT and AST)

1 = viral.

14

Alkaline phosphatase

30-150 iu/L
Raised in cholestasis, bone disease and pregnancy.

15

Gamma GT

30-150iu/L (also)
Raised in chronic alcohol use, bile duct disease and metastases. Also shows that high ALP is hepatic.