Psych 6 Flashcards

(46 cards)

1
Q

When should you consider diagnosis of MDE instead of bereavement following the lost of a loved one

A

Sx persist > 2 months, marked functional impairment, morbid preoccupations with unrealistic guilt or worthlessness, suicidal ideation, marked psychomotor retardation

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2
Q

First line tx for acute mania

A

Valproic acid

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3
Q

Side effects of valproic acid

A
  • GI distress (e.g. nausea and vomiting)
  • Increased appetite and weight gain
  • Tremor
  • Hepatotoxicity
  • Pancreatitis
  • Teratogenic
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4
Q

Side effects of lithium

A
  • Acute lithium toxicity = GI symptoms (nausea, vomiting, diarrhea)
  • Chronic lithium toxicity = Neurologic symptoms (e.g. tremor and ataxia)
  • Hypothyroid = Symptoms may include weight gain, dry skin, hair loss, constipation
  • Nephrogenic Diabetes Insipidus
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5
Q

Tx of persistent depressive disorder

A

Venlafaxine (SNRI) and Bupropion (DA/NE reuptake inhibitor)

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6
Q

What type of drug is Amoxapine

A

TCA

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7
Q

What percentage of new mothers is believed to experience postpartum blues?

A

30-75% in the 3 to 5 days after delivery

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8
Q

Differentiate between postpartum blues and postpartum depression

A

Blues = remit spontaneously in days to weeks

Depression = time of onset 3-6 months after delivery

Both have sleep disturbance, tearfulness, and depressed mood

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9
Q

How long after a stroke is a patient most likely to develop a post-stroke depression

A

6 months

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10
Q

Common trigger of manic episode in bipolar patients

+ tx?

A

Sleep deprivation

Can use long acting benzo to return normal sleep pattern and abort manic episode

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11
Q

What sx is associated with postpartum depression but not postpartum blues

A

Anhedonia

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12
Q

What is the most common side effect after ECT

A

HA

Most common complaints = HA, nausea, and muscle soreness. Memory impairment occurs but less frequently

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13
Q

Time frame of persistent depressive disorder

A

2 years in adults

1 year in kids!

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14
Q

Monitoring tests that should be done on patients taking Lithium

A

Creatinine, thyroid function, urinalysis

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15
Q

Sx that differentiate between bereavement and major depression

A
  • Guilt about things other than actions taken or not taken by the survivor at the time of loved ones death
  • Thoughts of death other than survivor feeling they would be better off with the loved one
  • Morbid preoccupation with worthlessness
  • Marked psychomotor retardation
  • Marked and prolonged functional impairment
  • Hallucinations other than the survivor hearing or seeing the loved one
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16
Q

Contraindication to ECT

A

MI within the past 4 weeks, increased ICP, aneurysms, bleeding disorders, conditions that disrupt BBB

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17
Q

What does brain imaging often display in depressed patients

A

Reduced metabolic activity and blood flow in both frontal loves on PET scan

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18
Q

What sx is the most accurate indicator of long-term suicidal risk in patients with MDD

A

Hopelessness

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19
Q

Describe sx of MDD with melancholic features

A
  • Loss of pleasure in all activities
  • Lack of reactivity (nothing can make patient feel better)
  • Intense guilt
  • Significant weight loss
  • Early morning awakening
  • Psychomotor retardation
20
Q

Tx of MDD with melancholic features

21
Q

What is double depression

A

When a major depressive episode develops in a patient with dysthymic disorder

22
Q

Likely diagnosis: Delirium + hemiparesis or other focal neuro signs or sx

A

CVA or mass lesion

23
Q

Likely diagnosis: delirium + elevated BP + papilledema

A

Hypertensive encephalopathy

24
Q

Likely diagnosis : Delirium + dilated pupils + tachycardia

A

Drug intoxication

25
Likely diagnosis : Delirium + fever + nuchal rigidity + photophobia
Meningitis
26
Likely diagnosis : Delirium + tachycardia + tremor + thyromegaly
Thyrotoxicosis
27
Potential medications for tx of Alzheimers
Anticholinesterase can slow deterioration | - Galantamine, Rivastigmine, Donepezil
28
Danger of antipsychotics in dementia patients
Carry a black box warning regarding increased risk of death in patients with dementia
29
Describe onset and characterization of Lewy body dementia
- Early onset dementia (Vs. Parkinson’s which has late onset dementia + Lewy bodies) - Characterized by dementia and visual hallucinations, followed by Parkinsonian features
30
Pharmacotherapy for Lewy Body Disease
* Cholinesterase inhibitors for cognitive and behavioral symptoms * Quetiapine or Clozapine for psychotic symptoms * Levodopa-carbidopa for Parkinsonism * Melatonin and/or Clozepam for REM sleep behavior disorder
31
Describe presentation of frontotemporal lobe dementia
- Cognitive defects in attention, abstraction, planning, and problem solving - Early = Behavior/personality changes (frontal lobe) and/or aphasia (temporal lobe) o Behavior = disinhibited, overeating, lack of emotional warmth/sympathy, apathy, perseveration, decline in social cognition and/or executive abilities o Language = difficulties with speech and comprehension - Late = Dementia
32
Clinical manifestations of Huntington's
* Triad of motor, cognitive, and psychiatric symptoms * Cognitive decline and behavioral changes can precede onset of motor signs by up to 15 years * Executive function is the primary cognitive domain affected * Psychiatric manifestations include depression, apathy, irritability, obsessions, and impulsivity * Patients are often aware of deteriorating mentation * Movement disorders include chorea and bradykinesia
33
Clinical manifestation of Parkinson's
* Motor signs include rigidity, resting tremor, bradykinesia, and postural instability * Cognitive manifestations consist of executive dysfunction ad visuospatial impairments * Depression, anxiety, personality changes, and apathy are common * Psychotic symptoms. Including visual hallucinations and paranoid delusions, may result from the disease itself or as adverse effects of medications used to treat the motor symptoms
34
Tx of parkinson's
* Carbidopa-levodopa for motor symptoms * Cholinesterase inhibitors to target cognitive symptoms * Reduction in dopamine agonists for psychotic symptoms * Quetiapine and Clozapine are preferred for treatment of psychotic symptoms that are not responsive to dopamine dose reduction
35
Clinical manifestation of prion disease
* Insidious onset with rapidly progressive cognitive decline * Difficulties with concentration, memory, and judgment occur early * More than 90% of patients experience myoclonus * Depression, apathy and hypersomnia are also common * Basal ganglia and cerebellar dysfunction, manifesting as ataxia, nystagmus, and hypokinesia, are present in a majority of individuals
36
Tx of Prion disease
* No effective treatment exists | * Most individuals die within 1 year of diagnosis
37
Tx of Borderline personality disorder
DBT
38
What are the 4 categories of Extra-pyramidal symptoms in the order they appear
1. Dystonia 2. Akathisia 3. Pseudoparkinsonism 4. Dyskinesia
39
What is dystonia
Sustained abnormal posturing (e.g. oculogyric crisis, laryngospasm, torticollis)
40
Tx of Dystonia
Botox for torticollis | Benztropine or diphenhydramine
41
What is akathisia
Motor restlessness; crawling sensation in legs relieved by walking
42
Tx of akathisia
Lorazepam, Propanolol or Diphenhydramine
43
What is pseudoparkinsonism
TRAPS: Tremor, rigidity, akinesia, postural instability, staggering gait
44
Tx of pseudoparkinsonism
Benztropine
45
What is tardive dyskinesia
Purposeless, constant movements, involving facial and mouth musculature
46
Tx of tardive dyskinesia
No good treatment; discontinue drug or reduce dose