Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

NAPLEX review 2024 RXPrep Book > Psychiatric Conditions: Depression > Flashcards

Psychiatric Conditions: Depression Flashcards

(51 cards)

Start Studying
1
Q

DSM-5 Criteria

A

at least 2 of the following symptoms present during the same two week period

Mood = Depressed
Sleep = inc/dec
Interest/pleasure = diminished
Guilt or feelings of worthlessness
Energy = decreased
Concentration = decreased
Appetite = inc/dec
Psychomotor agitation or retardation
Suicidal ideation

M SIG E CAPS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Bipolar disorder should be ruled out before starting antidepressant therapy to….

A

avoid inducing mania or causing rapid-cycling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Natural products that maybe helpful for depression

A

St John’s Wort
SAMe
valerian
5-HTP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How long is suitable trial for depression

A

4-8 weeks, if drug doesn’t work then reassess

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

SSRI use in pregnant women warning

A

risk of persistent pulmonary hypertension of newborn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Symptoms of serotonin syndrome

A

severe nausea
dizziness
headache
diarrhea
agitation
tachycardia
hallucinations
muscle rigidity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How to discontinue antidepressant

A

taper over a few weeks to avoid withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

boxed warnings for all antidepressants

A

possible increase in suicidal thoughts or actions in some children, teenagers, young adults in first few months of txm or when dose changed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SSRIs

A

Citalopram = Celexa
Escitalopram = Lexapro
Fluoxetine = Prozac
Paroxetine = Paxil
Sertraline = Zoloft

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Citalopram (Celexa) dosing

A

20-40mg
Max: 40mg/day, 20mg in > 60yrs old

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Escitalopram (Lexapro) dosing

A

Max 20mg/day, 10mg/day elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fluoxetine (Prozac) dosing

A

Max 80mg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SSRI Contraindications

A

dont use with MAOi, Linezolid, IV methylene blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

SSRI warnings

A

QT prolongation: dont give more than 20mg citalopram elderly, 10mg escitalopram elderly

SIADH, hyponatremia, fall risk
Bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

SSRI side effects

A

Sexual side effects
Somnolence, insomnia, nausea, dry mouth, weakness, tremors, dizziness, headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Most activating SSRI

A

Fluoxetine, take in AM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Most sedating SSRI

A

paroxetine, fluvoxamine, take in PM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

SSRI preferred for patients with cardiac risk?

A

Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Washout period for SSRI and MAOi

A

2 weeks for most, 5 wks for Fluoxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Vilazodone (Viibryd) MOA

A

SSRI and 5-HT1A partial agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Vortioxetine (Trintellix) MOA

Study These Flashcards
A

SSRI, 5-HT3 receptor antagonist, 5-HT1A agonist

22
Q

Vilazodone (Viibryd) & Vortioxetine (Trintellix) CI, warnings, SE

Study These Flashcards
A

CI: dont use within 14 days of MAOi
Warnings: seizures, avoid pts with seizure hx
Side effects: N/V/D, less sexual side effects

23
Q

SNRI

Study These Flashcards
A

Venlafaxine = Effexor
Duloxetine = Cymbalta
Desvenlafaxine = Pristiq

24
Q

SNRI contraindications

Study These Flashcards
A

Dont use SNRI/MAOi combo

25
SNRI warnings
fall risk, SIADH/hyponatremia, bleeding
26
SNRI side effects
similar to SSRI inc HR, dilated pupils, dry mouth, excessive sweating and constipation due to inc NE
27
Which SNRI has greatest risk of inc BP?
venlafaxine when dosed > 150mg/day
28
Secondary vs Tertiary Amine TCA
Secondary = selective Tertiary = can be more effective but worse side effects
29
Tertiary Amines TCAs
Amitriptyline Doxepin Clomipramine Imipramine Trimipramine
30
Secondary Amines TCAs
Nortriptyline = Pamelor Amoxapine Desipramine Maprotiline Protriptyline
31
TCA contraindications
Dont use with MAOi, linezolid, IV methylene blue
32
TCA side effects
Cardiotoxicity: QT prolongation with OD, orthostasis, tachycardia Anticholinergic: Dry mouth, blurred vision, urinary retention, constipation, vivid dreams, weight gain, risk of calls
33
Dopamine and NE reuptake inhibitor
Bupropion = Wellbutrin
34
Bupropion max dose
450mg/day due to seizure risk
35
Bupropion Contraindications
seizure disorder hx of anorexia/bulimia dont use with MAOi, linezolid, methylene blue
36
Bupropion warnings
Neuropsychiatric adverse events when used for smoking cessation possible
37
Bupropion side effects
Dry mouth CNS stimulation weight loss sexual dysfunction is rare
38
MAOi medications
Isocarboxazid = Marplan Phenelzine = Nardil Tranylcypromine = Parnate Selegiline = Emsam = MAO-B selective
39
MAOi contraindications
hx of CVD, cerebrovascular defect, HA, hepatic disease severe renal disease
40
MAOi warnings
hypertensive crisis or serotonin syndrome can occur with TCA, SSRI, SNRIs, tyramine rich foods
41
MAOi side effects
anticholinergic effects Orthostasis Sedation sexual dysfunction weight gain
42
Selegiline (Emsam) CI and side effects
CI: use with serotonergic drugs Side effects: constipation, gas, dry mouth, loss of appetite, sexual dysfunction
43
Tyramine containing foods
aged cheese pickled herring yeast extract air-dried meats sauerkraut soy sauce fava beans some red wines and beers aged, fermented or smoked foods
44
Mirtazapine (Remeron) info
used often in one to help with sleep, inc appetite/ weight gain
45
Trazodone info
used mostly off label for sleep SE: sexual dysfunction and priapism
46
Nefazodone info
rarely used due to hepatotoxicity, boxed warning
47
Aripiprazole (Abilify) side effects
anxiety insomnia akathisia constipation agitation
48
Olanzapine (Zyprexa) side effects
sedation, weight gain, inc lipids/glucose, EPS, QT prolongation - lower risk
49
Quetiapine (Seroquel) side effects
sedation, orthostasis, weight gain, inc lipids/glucose, EPS - lower risk
50
Brexpiprazole (Rexulti) side effects
weight gain, dyspepsia, diarrhea
51
Esketamine (Spravato) info
C3, comes as nasal spray Given under supervision of HCP REMS program

NAPLEX review 2024 RXPrep Book (78 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions