Quick Study Side Effects

Question 1

Side effects of ACEi

Answer 1

Cough
Postural hypotension (with Diuretics)
Angioedema 
Renal dysfunction
Rash
GI- diarrhoea, bloating, nausea, vomiting, changes in taste

Question 2

Side effects of amiodarone

Answer 2

Corneal microdeposits
Thyroid dysfunction
Hepatotoxicity
Pulmonary toxicity
Peripheral neuropathy

Question 3

Monitoring in amiodarone

Answer 3

LFT, TFT, before and every 6 months

CXR and electrolytes before

Question 4

CI amiodarone

Answer 4

Iodine sensitivity
Heart block
Thyroid disease
Some arrhythmics (Brady)

Question 5

Side effects NSAIDs

Answer 5

Renal dysfunction
Increased bruising
Ulcers

Question 6

Side effects of warfarin

Answer 6

Bleeding
Teratogenic
Necrosis of soft tissue- protein C (toes!)

Question 7

Warfarin potentiators

Answer 7

Liver disease
High metabolic rate e.g. thyroid
Aspirin and NSAIDs

ODEVICES

OMEPRAZOLE
DISULFRAM
ERYTHROMYCIN
VALPROATE
ISONIAZID
CEMETIDINE
ETHANOL - ACUTE
SULPHONAMIDES

Question 8

Decrease warfarin effects

Answer 8

Pregnancy
Hypothyroidism
Vitamin K- kale, broccoli

PCBRAS
PHENYTOIN
CARBAMAZEPINE 
BARBITUATES
RIFAMPICIN
ALCOHOL- CHRONIC
SULPHONYLUREAS

Question 9

Side effects beta blockers

Answer 9

Bradycardia
HypotensionBronchospasm
Cold fingers
Fatigue
Dizziness
Heart block

Question 10

Side effects calcium channel blockers

Answer 10

Reflex tachycardia
Ankle swelling
Hypotension
Headache

Question 11

Statin side effects

Answer 11

Myalgia
GI
Hepatic
Rash
Insomnia
Myositis

Avoid grapefruit

Question 12

Side effects SSRIs

Answer 12

GI
Appetite and weight change
Headaches
Drowsiness (can take at night)
Anxiety (2 weeks)

Withdrawal

Question 13

Contraindications to SSRI

Answer 13

Suicide risk—> refer

Mania

Question 14

Monitoring in methotrexate

Answer 14

FBC, LFTs, U&Es

Before starting
Every 2 weeks until stable
Then 2-3 months

Question 15

Sid effects methotrexate

Answer 15

Alopecia
Headaches
GI

Myelosupression

• infection —> A&E
• unexpected bleeding/bruising
• Anaemia

Question 16

Complications of methotrexate

Answer 16

Myelosupression
Hepatic- alcohol
Pulmonary- SOB

Question 17

Methotrexate contraindications

Answer 17

Baby
Hepatic
Breastfeeding 
Infection
immunodeficiency

Question 18

Monitoring in lithium

Answer 18

Before- U&Es , FBC, TFTs, bHCG, ECG

Lithium levels weekly until stable for 4 weeks then every 3 months

TFT, U&Es Ca2+ every 6 months

Question 19

Side effects lithium

Answer 19

GI
Metallic taste
Tremor
Water symptoms- SIADH

Toxicity

• GI
• neuromuscular- dizziness, dysarthria, ataxia, twitching, restlessness

Question 20

Complications of lithium

Answer 20

Renal
Diabetes insipidus
Hypothyroidism

Question 21

Contraindications to lithium

Answer 21

Pregnancy
Breast feeding
Cardiac
Renal
Addison’s
Low sodium diet
Hypothyroidism

Question 22

Onlanzapine monitoring

Answer 22

Occasional LFTs

Question 23

Side effects onlanzapine

Answer 23

Anti-dopaminergic- tardive dyskinesia, tremor, movement disorders
Anti-cholinergic- constipation, dry mouth
Anti-histaminergic- weight gain, dizziness, drowsiness
Anti-adrenergic- hypotension

Question 24

Complications onlanzapine

Answer 24

Neuroepilaptic malignant Syndrome

• Fever
• Muscle rigidity

Agranulocytosis

• Infections
• swelling
• rash

Question 25

Contraindications onlanzapine

Answer 25

Liver failure Phaeochromocytoma ``` Cautions Epilepsy DM Glaucoma Parkinson’s Heart, prostate, kidney problems Pregnancy ```

Question 26

Levodopa side effects

Answer 26

Psychosis N&V Dyskinesia Postural hypotension Drugs can help Contraindicated in glaucoma

Question 27

Side effects bisphosphonates

Answer 27

``` Headache Heartburn Bloating Indigestion GI ```

Question 28

Contraindications for bisphosphonates

Answer 28

Pregnancy Dysphagia Ulcers Renal

Question 29

Levothyroxine monitoring

Answer 29

Test dose- 2-3 weeks TSH every 2/3 months until stable TSH annually if stable

Question 30

Side effects levethyroxine

Answer 30

Rare May be hyperthyroid, or hypo if levels are too low

Question 31

Side effects metformin

Answer 31

Nausea, diarrhoea, abdopain, weight loss

Question 32

Contraindications metformin

Answer 32

Renal Ketoacidosis Low BMI If miss a dose, take asap, but not if close to next dose

Question 33

How take iron tablets?

Answer 33

Work best if empty stomach | Most take with food as can cause GI upset

Question 34

Monitoring iron tablets

Answer 34

Takes 3-4 weeks to increase Hb ( FBC) | 3 months to replenish stores

Question 35

Side effects iron tablets

Answer 35

GI - nausea, sickness, diarrhoea, abdo pain Coloured stools Taste bad