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Flashcards in Rabdovirus Deck (20)
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1

Retroviruses have a diploid genome. This means:
- They have two segments of dingle stranded, positive sense RNA
- They have two nucleocapsids
- They have a double stranded RNA
- They have a double envelop

They have two segments of dingle stranded, positive sense RNA

2

The reverse transcriptase is required for:
- Copying cDNA from viral RNA during retroviral replication
- Retroviral exocytosis
- Retroviral entry into cells
- Retroviral integration into host genome

Copying cDNA from viral RNA during retroviral replication

3

Where does the reverse transcriptase required for copying cDNA from viral RNA come from?
- It is de novo synthesized in the infected cell mitochondria
- Since RNA viruses use cellular mechanisms for replication, the source of RT is the host cell
- RT is found on the surface of the infected cell
- The RT is virion-associated

RT is found on the surface of the infected cell

4

Where in the infected cell does reverse transcription of the retroviral RNA take place?
- Cytoplasm
- Nucleus
- Mitochondria
- Endothelial reticulum

Cytoplasm

5

What is a provirus?
- The genetic material of a virus as incorporated into, and ale to replicate with, the genome of a host cell
- RNA derived from a bacterial virus
- Another name for prions
- Any type of DNA incorporated into a cell

The genetic material of a virus as incorporated into, and ale to replicate with, the genome of a host cell

6

Where in the host genome does the retroviral dsDNA integrate?
- There is no one site specificity for viral dsDNA integration
- Only at sites where proto-oncogenes are located
- At sites where introns are situated
- Integration takes place only between exons

There is no one site specificity for viral dsDNA integration

7

What does the pol gene of retroviruses encode?
- Reverse transcriptase and integrase
- Protease
- Surface (SU) and transmembrane (TM)
- Capsid (CA), nucleocapsid (NC), matrix (MA)

Reverse transcriptase and integrase

8

FIV can infect
- CD4+ T lymphocytes
- All of the above
- Platelets
- Microglial cells

- CD4+ T lymphocytes

9

The most important route of FIV in domestic cats is:
- Sexual contact
- Grooming, exclusively
- Fomites
- Bite wounds

- Bite wounds

10

FELV has tropism to cells of the immune system such as T cells
- True or false

True

11

During which virus infection can lymphoma and leukemia develop?
- NDV
- FeLV
- Influenza A
- Swine poxvirus

- FeLV

12

What outcome of retrovirus infection do you know?
- Cellular transformation
- Latent infection
- Chronic infection
- All of the above

- All of the above

13

Acute transformation by retroviruses is mediated y oncogenes
- True or false

True

14

What type of cellular transformation do retroviruses cause by insertion or mutation through random integration
- None of the above
- Chronic transformation
- Blastic transformation
- Acute transformation

- Chronic transformation

15

A non-vaccinated cat can have antibodies against FeLV even though it has not been infected with an exogenous FeLV
- True or false

True

16

The replication strategy of retroviruses requires rewriting viral RNA into viral DNA. This process is referred to as
- Reverse transcription
- Translation
- Reverse translation
- Oncogenesis

- Reverse transcription

17

Apart for CCR5 and CXCR4 FIV can also enter cells through other receptors such as:
- CD8
- CD335
- CD95L
- CD4

- CD4

18

From the options below, choose the best for method of disinfection of viruses belong to the retroviridae family
- Exposure to UV rays for 15 minutes
- Acid-based disinfectant
- Lipid solvent-based disinfectant
- Alakaline-based disinfectant

Lipid solvent-based disinfectant

19

During FeLV infection it is possible that in some cats the immune system may completely eliminate the virus
- True or false

True

20

How long is the incubation period of FIV?
- 3 days
- 1 month
- 1 week
- May be as long as 6 years

- May be as long as 6 years