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Flashcards in Paramyxoviridae Deck (20)
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1

Paramyxoviruses can replicate in enucleated cells or cells treated with actinomycin D
       True 
       False 

True

2

Which of the following replication strategies fit the paramyxovirus?
A. Cytoplasmic uncoating and reverse transcription, nuclear dsDNA integration in host genome and transcription, cytoplasmic protein translation, virion assembly and budding
B. Nuclear uncoating, cytoplasmic synthesis of mRNA and RNA(+), translation of non-structural proteins, assembly of virions
C. Cytoplasmic uncoating, nuclear synthesis of mRNA, and cRNA(+) and vRNA(-), cytoplasmic translation of proteins, virion assembly and budding
D. Cytoplasmic uncoating, cytoplasmic synthesis of both mRNA and +RNA, cytoplasmic translation of structural proteins from mRNA, cytoplasmic synthesis vRNA(-) from +RNA, virion assembly and budding

D. Cytoplasmic uncoating, cytoplasmic synthesis of both mRNA and +RNA, cytoplasmic translation of structural proteins from mRNA, cytoplasmic synthesis vRNA(-) from +RNA, virion assembly and budding

3

Replication of paramyxovirus occurs primarily in this location:
      A.  Mitochondria
      B . Nucleus
      C.  Endothelial reticulum
      D. Cytoplasm

      D. Cytoplasm

4

How many types of glycoprotein spikes are there on the surface envelope of Paramyxoviridae?
       A. 2
       B. 1
       C. 4
       E. 3

       A. 2

5

According to the FAO and OIE, Rinderpest has been eradicated
       True 
       False 

True

6

Giant, multinucleated cells that develop during paramyxovirus replication are also known as a what?
      A. Synclines
      B. Syncytia
      C. Syncopates
      D. Synchrotrons

      B. Syncytia

7

AVPM-1 is a member of what sub-family of viruses?
      A. Paramyxovirinae
      B. Filovirinae
      C. Retrovirinae
      D. Orthomyxovirinae

      A. Paramyxovirinae

8

Nipah virus naturally infects fruit bats, humans and swine are NOT susceptible.
       True 
       False

False

9

To which family of viruses do the Paramyxovirinae and Pneumovirinae belong?
     A. Paramyxvoviridae
      B. Birnaviridae
      C. Orthomyxoviridae
      D. Rhabdovirdae

     A. Paramyxvoviridae

10

Members of the Paramyxoviridae do not require nuclear function to replicate
       True 
       False

True

11

Syncytium is formed in cell culture following infection with Paramyxovirus. Syncytium is:

A. Formation of large, multinucleated cells in culture
B. Formation of synchrotrons in cells infected with APMV-1
C. Formation of synclines in infected cells
D. Formation of syncopates in cell culture

B. Formation of synchrotrons in cells infected with APMV-1

12

12. Which of the following are pathotypes of APMV-1 (NDV)? (Points : 2)
      
Lentogenic
Mesogenic
Velogenic (viscerotropic/neurotropic)
All of the above

All of the above

13

Nipah virus is an emerging zoonosis
       True 
       False

True
BSL -4**

14

Secondary immunodeficiency is likely to develop during canine distemper. Why?
       destruction of nasal epithelial tissue
       destruction of nasal associated lymphoid tissue
       destruction of dendritic cells, macrophages, thymocytes and activated T cells
       destruction of the nervous system

  destruction of dendritic cells, macrophages, thymocytes and activated T cells

15

What receptor should be expressed on a cells for the canine distemper virus to infect that cell?
       CD4
       CD150
       CXCR4
       CCR5

       CD150

16

Canine distemper in dogs is now a rare disease in North America. Why?
       all virus reservoirs have been eliminated
       quarantine and elimination of infected dogs
       systematic vaccination of dogs
       the virus has been eradicated

 systematic vaccination of dogs

17

17. You are called on to a puppy that has been bitten by a raccoon. The client managed to capture the raccoon. Upon visual examination of the raccoon you notice neurological signs similar to canine distemper. Is there anything you could do to prevent canine distemper in the non-vaccinated puppy?
       Yes, administer hyperimmune serum against canine distemper virus
       Nothing can be done, just dress the bite wound and hope for the best.
       Yes, vaccinate immediately
       No, the puppy should be quarantined and eliminated if canine distemper develops

Yes, administer hyperimmune serum against canine distemper virus

18

Further consider the events in the previous question. What other suspicion could arise regarding the state of the raccoon?

       it could be infected with the rabies virus
       it could be infected with a feline retrovirus
       the raccoon could have drunk some alcohol found in the dumpster, hence gait abnormality
       it could be infected with the classical swine fever virus

 it could be infected with the rabies virus

19

Samples from chicken suspected of velogenic NDV infection should be sent to:

       any laboratory that can process the samples
       nearest diagnostic laboratory as soon as possible
       the best diagnostic laboratory in the country
       a reference laboratory

      a reference laboratory

20

During an outbreak of FMD, what disinfectant, in form of soaked mats, would you choose to safeguard the entrance to animal houses?
       picric acid
       sodium hydrogen sulphate
       sulphuric acid
       soda ash

       soda ash