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Flashcards in Picornaviridae Deck (20)
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1

SVD is a vesicular disease that has not been reported in North America. What other vesicular diseases of cattle, swine or horses do you know?
       vesicular stomatitis
       foot-and-mouth disease
       vesicular exanthema of swine
all of the above

all of the above

2

The pig is the only natural host of Swine Vesicular Disease Virus.
       True 
       False 

True

3

What is the difference between positive and negative sense viral RNA?
       there is no difference because both types of RNA are translated in the cytoplasm
       no answer is correct
       viral proteins can be translated directly only from the positive sense RNA
       there is no difference because both encode viral genes

 viral proteins can be translated directly only from the positive sense RNA

4

Sodium carbonate is a disinfectant of choice during FMDV outbreaks
       True 
       False 

True

5

The Picornaviridae genome is organized in one open reading frame (ORF). What does this imply for protein translation?
       no answer is correct
       protein expression will be delayed
       protein translation will ensue as a single polypeptide
       protein expression will be difficult

 protein translation will ensue as a single polypeptide

6

Swine vesicular disease virus is sensitive to ambient temperature and to sodium carbonate.
       True 
       False 

False

7

How would you clinically distinguish between Foot-and-mouth disease, Swine Vesicular disease and vesicular stomatitis in pigs?
       lesions in vesicular stomatitis are located only in the oral cavity
       lesions in swine vesicular disease are found throughout body
       lesions in foot-and-mouth disease are located mostly on feet
       lesions are indistinguishable, laboratory diagnosis is necessary

 lesions are indistinguishable, laboratory diagnosis is necessary

8

There is cross protection between the 7 serotypes of FMDV, which makes it easy to vaccinate against FMD.
       True 
       False

False

9

If FMDV was present on a farm with a mixture of animals such pigs, goats, sheep and cattle, which animal species would manifest clinical signs first?
       horses
       sheep
       cattle and pigs
       goats

       cattle and pigs

10

Pigs are always referred to as amplifiers of FMDV. What does this mean?
       virion size of FMDV in pigs is twice that in cattle
       replication of FMDV in pigs is intensive, resulting in a high concentration of virus on the premises
       pigs have more vesicles than cattle
       FMDV isolated from pigs is easily amplified by PCR

replication of FMDV in pigs is intensive, resulting in a high concentration of virus on the premises

11

Which of the following statements is a consequence of FMDV infection in livestock?
       limitation of international trade in livestock and animal products
       economic losses to farmers and producers
       loss in livestock production
all of the above

all of the above

12

The following are routes of FMDV transmission: aerosols, direct contact and indirect contact via fomites.
       True 
       False 

True

13

In FMD-free countries such the UK, how is FMD controlled when an outbreak occurs?
       none of the above
       vaccination
       treatment of infected animals
       quarantine, euthanization and disposal

 quarantine, euthanization and disposal

14

In North America who is authorized to handle diagnostic samples for FMD?
       only veterinary hospitals
       veterinary research centres
       only reference laboratories
       any diagnostic laboratory can handle such samples as long as they have appropriate equipment to run the tests

only reference laboratories

15

What is your best choice of clinical samples for FMDV or SVD testing?
       nasal swabs
       skin scrapings
       oral swabs
       blood, vesicular fluid, raptured vesicular swabs

blood, vesicular fluid, raptured vesicular swabs

16

Numerous assays have been developed to detect FMDV or SVDV in clinical samples. What assays would you choose to achieve rapid detection and confirmation of these viruses?
       virus isolation in cell culture
       RT-PCR, ELISA, virus isolation, in that order
       western blot
       inoculation of embryonated chicken eggs

 RT-PCR, ELISA, virus isolation, in that order

17

To which virus family and genus does FMDV belong?
       Picornaviridae, enterovirus
       Filoviridae, aphtovirus
       Picornaviridae, aphtovirus
       Paramyxoviridae, aphtovirus

       Paramyxoviridae, aphtovirus

18

Which of the following strategies of cell entry can be employed by members of the picornaviridae?
       endocytosis
       VP4 and VP1 mediated injection of the capsid
       membrane fusion
all options are correct

all options are correct

19

What are the prominent locations of FMD lesions in cattle and pigs?
       oral mucosal only
       foot and mouth
       all over the body
       exclusively on coronary bands

       foot and mouth

20

FMD is a highly contagious disease that always results in:
       high morbidity and mortality
       high morbidity
       high mortality
all of the above.

       high morbidity