Bornaviridae, Astroviridae & Prions Flashcards Preview

RUSVM Virology RNA viruses > Bornaviridae, Astroviridae & Prions > Flashcards

Flashcards in Bornaviridae, Astroviridae & Prions Deck (20)
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1

Borna disease virus is mostly detected in?
       USA
       Iceland
       Africa
       Central Europe

       Central Europe

2

The fatal form of Borna disease is:
       the neurological disease       
 the gastrointestinal disease
       the reproductive tract disease
       the mucosal disease

 the neurological disease

3

“Dribbling and champing of jaws” is a clinical sign of Borna disease.
       True 
       False 

True

4

Eosinophilic intranuclear inclusion bodies in neurons called “Joest-Degen" bodies are pathognomonic for Borna disease Virus infection.
       True 
       False 

True

5

Ante-mortem diagnosis is of Borna disease is difficult mainly because of similarities in neurological manifestation. Which is of following diseases can be considered as differentials?
      
       EHV-1 infection
       rabies
       West Nile
All above options are valid

  All above options are valid

6

What disease does the avian bornavirus cause?
       rhinotracheitis
       osteopetrosis
       “Big leg” syndrome
       Proventricular dilatation disease

   Proventricular dilatation disease

7

During infection with the avian bornavirus, proventricular dilatation is a direct result of:
       progressive indigestion
       progressive neurological dysfunction
       diarrhoea
       inappetence

  progressive neurological dysfunction

8

Although Astroviruses are known to cause diarrhoea in many animal species, however, a fatal diarrheic disease can be observed only in:
       birds
       humans
       pigs
       cattle

birds

9

Astroviruses have a linear, positive sense, single-stranded RNA and the RNA is:
       semi-infectious
       quiescent
       non-infectious
       infectious

infectious

10

The term prion means:
       primitive form of virus
       infectious protein or rogue protein
       non-infectious protein
       precarious protein

  infectious protein or rogue protein

11

What classification system is used for prions?
       microorganism classification system
       Bergey's manual of systematic bacteriology
       There is no classification system for prions yet
       International committee on taxonomy of viruses

There is no classification system for prions yet

12

What is the abnormal form of the prion protein?
       PrPsc
       PrPc
       PrP
       PrPs

PrPsc

13

Prion proteins are mostly expressed in:
       muscle cells
       enterocytes
       neurons and lymphoreticular cells
       skull osteocytes

neurons and lymphoreticular cells

14

Why are prions difficult to eliminate?
       there envelope coat is resistant to proteases
       they are resistant to chemical and physical conditions
       they are made of RNA that is resistant to ultraviolet light
       they are invisible

  they are resistant to chemical and physical conditions

15

How do prions replicate?
       they use reverse transcriptase to transcribe their genetic material
       they are amplified by Taq polymerase
       by transduction
       the PrPsc catalyses the conversion of PrPc into PrPsc

 the PrPsc catalyses the conversion of PrPc into PrPs

16

Scrapie is a prion disease mainly found in:
       pigs
       sheep
       camels
       cattle

sheep

17

In animals infected with the scrapie prion, histopathological lesions are characterized by wide spread inflammatory reaction in the brain.
       True 
False

False

18

Why has prion infection in cattle been termed “mad cow disease”?
       constant mooing of the affected animal
       aimless wondering of the affected animal
       Abnormal posture and progressive apprehensive behaviour of the affected animal
       weight loss of the affected animal

Abnormal posture and progressive apprehensive behaviour of the affected animal

19

Although the transmission of prions is not fully known, what is the accepted mode of transmission currently?
       oral route
       ticks
       mosquitoes
       thrips

   oral route

20

Histopathological examination of a brain from a cow suspected to have died from Bovine spongiform encephalopathy would show:
       Astrocytic hypoplasia
       Neuronal vacuolation and degeneration
       lymphocytes infiltration around neurons
       vestibular neuronitis

Neuronal vacuolation and degeneration