random

Question 1

What antibodies do you test for for sjogrens syndrome?

Answer 1

ANTI-SSA
ANTI-SSB
ANA
RF

Question 2

What are the manifestations of sjogrens?

Answer 2

-keratoconjunctivitis sicca
-dry mouth ->difficulty talking, swallowing, eating, etc.

Question 3

which glands could be biopsied to confirm sjogrens?

Answer 3

salivary glands

Question 4

what is the name of the ocular test for moisture?

Answer 4

Schirmer test

Question 5

What is an abnormal schirmer test result?

Answer 5

<5mm of moisture after placing the sterile strip under the lower eyelid for 5 minutes

Question 6

what is the name of the muscarinic antagonist that can be used in sjogrens?

Answer 6

pilocarpine (oral dosing)

Question 7

CI to pilocarpine use

Answer 7

angle-closure glaucoma and asthma

Question 8

how do you manage xerostomia in sjogrens?

Answer 8

-advise daily antibacterial mouthwashes/fluoride use
-OTC salivary drops
-sugar free gum/losenges
-oral pilocarpine

Question 9

what is the typical treatment for ovarian cancer?

Answer 9

Surgical tumor cytoreduction (debulking surgery) followed by a combination of
platinum and nonplatinum (taxane-based) chemotherapy

Question 10

What is the prognosis of stage I ovarian ca?

Answer 10

90% at 5 years

Question 11

What is the prognosis of stage IV ovarian cancer?

Answer 11

<10% at 5 years

Question 12

interstitial cystitis aka

Answer 12

painful bladder syndrome

Question 13

Differentials for interstitial cystitis

Answer 13

-STI
-pelvic floor pathology
-bladder tumour
-overactive bladder
-endometriosis
-prostatitis

Question 14

which food/drinks should be avoided in interstitial cystitis?

Answer 14

-caffeine
-alcohol
-spicy foods
-vit C

Question 15

what are the non-pharmacologic management options of interstitial cystitis?

Answer 15

-heating pads
-avoiding triggers
-bladder training
-psychosocial support/stress management

Question 16

what are the pharmacological treatment options for interstitial cystitis?

Answer 16

-amitryptyline
-pentosan polysulfate sodium
-hydroxyzine (antihistamine)
-gabapentin
-amitryptilline

Question 17

how does pentosan polysulfate sodium work?

Answer 17

it coats the deficient inner lining of the bladder and prevents mast cells from degranulating

Question 18

what is the most common comorbid disorder with OCD?

Answer 18

MDD

Question 19

where are the most common sites of statin myopathy?

Answer 19

thighs and calves

Question 20

what are the patient related risk factors for statin myopathy?

Answer 20

age >80
female
concurrent hypothyroidism
alcohol use
low BMI
Hx of myopathy on other lipid lowering agents
multisystem disease

Question 21

what are medication related risk factors for statin myopathy?

Answer 21

high dose statin therapy
interactions with other drugs (amiodarone, fibrates, verapimil, antifungals)

Question 22

how long do statin myopathy symptoms last following cessation of the statin?

Answer 22

avg 2.3 months

Question 23

what are the two most common stroke mimics?

Answer 23

-hypoglycemia
-seizure

Question 24

which statins have the lowest risk for myopathy?

Answer 24

rosuvastatin
pravastatin
fluvastatin

Question 25

what finding in a cerebropspinal tap confirms subarachnoid hemorhage?

Answer 25

bilirubin (red blood cells could be present from a traumatic tap, but they would not have been broken down into bilirubin)

Question 26

what is the most specific sign in asthma?

Answer 26

wheezing

Question 27

Diagnostic criteria for asthma in children under 5

Answer 27

1. History compatible with asthma 2. Evidence of airflow obstruction on exam WITH reversibility 3. No other more likely diagnosis

Question 28

Diagnostic criteria for children 6+ for asthma

Answer 28

FEV1/FVC <0.8 AND increased FEV1 at least 12% with bronchodilator

Question 29

Diagnostic criteria for asthma in adults

Answer 29

FEV1/FVC <0.8 AND increased FEV1 at least 12% (OR greater than 200mL) with bronchodilator

Question 30

what medication should patients with asthma considering avoiding?

Answer 30

NSAIDS (10-20% are sensitive)

Question 31

What are the pharm managment strategies by step for asthma?

Answer 31

Step 1: SABA PRN Step 2: Add low dose ICS Step 3: Medium dose ICS Step 4. Specialist-> LRTA, LABas

Question 32

Indications for referral to a specialist for asthma management (list 3)

Answer 32

-History of ICU admission -Poor asthma control despite medium ICS (persistent symptoms or hospitilization or necessity for course of oral steroids) -Atypical symptoms or unclear diagnosis