Random

Question 1

Unconjugated hyperbilirubinemia. AD. Decreased UGT1A1 activity. Mild, but occasionally causes kernicterus

Answer 1

Crigler Najjar Syndrome Type 2

Question 2

Unconjugated hyperbilirubinemia. AR. Decreased UGT1A1. Innocuous

Answer 2

Gilbert

Question 3

AR. Conjugated hyperbilirubinemia. Decreased biliary excretion. Innocuous

Answer 3

Dubin-Johnson

Question 4

Mutation in Canalicular MDR protein 2 (MRP2)

Answer 4

Dubin-Johnson

Question 5

Pigmented cytoplasmic globules in liver

Answer 5

Dubin-Johnson

Question 6

AR. Conjugated hyperbilirubinemia. Decreased hepatocyte uptake and storage. Decreased biliary excretion. Innocuous.

Answer 6

Rotor syndrome

Question 7

Hem > biliverdin by

Answer 7

Heme oxygenase

Question 8

Biliverdin > unconjugated bilirubin by

Answer 8

Biliverdin reducatase

Question 9

Unconjugated bilirubin > conjugated bilirubin by

Answer 9

UDPGT (glucuronyl-bilirubin transferase)

Question 10

Conjugated bilirubin is excreted in

Answer 10

Bile

Question 11

Stercobilin is excreted in

Answer 11

Stool

Question 12

Urobilin is excreted in

Answer 12

Urine

Question 13

Unconjugated hyperbilirubinemia. AR. No UGT1A1 activity. Fatal in neonatal period.

Answer 13

Craiger Najjar syndrome type 1

Question 14

Middle aged and older. Common in USA. ANA and ASMA

Answer 14

Type 1 autoimmune hepatitis

Question 15

Children and teenagers. Southern Europe. Anti-LKM1

Answer 15

Type 2 autoimmune hepatitis

Question 16

Attacks CYP2D6 on plasma membrane of cell

Answer 16

Anti-LKM1

Question 17

Cholestasis, vascular lesions, neoplasms

Answer 17

OC

Question 18

Fatty liver disease, fibrosis, cirrhosis, neoplasms

Answer 18

Alcohol

Question 19

Fatty liver disease, fibrosis, cirrhosis

Answer 19

Methotrexate

Question 20

Hepatocellular necrosis

Answer 20

Acetaminophen

Question 21

Max daily dose of acetaminophen is

Answer 21

4,000 mg

Question 22

Chlorpromazine and halothane are directly toxic to the

Answer 22

Liver

Question 23

Increased lipid synthesis, increased peripheral fat catabolism, and abnormal lipoproteins

Answer 23

Steatosis

Question 24

Reversible with abstinence

Answer 24

Steatosis

Question 25

Macro and micro vesicular steatosis. Mallory-Denk bodies

Answer 25

Alcoholic liver disease

Question 26

80 grams or more alcohol daily

Answer 26

Severe liver injury

Question 27

Iron overload, Hep B, and Hep C are _____ with alcohol

Answer 27

Synergistic - cause more severe effects

Question 28

Necrosis, inflammation, Mallory bodies, fatty change

Answer 28

Hepatitis

Question 29

AST > ALT

Answer 29

Alcoholic hepatitis

Question 30

Perisinusoidal and pericellular fibrosis (chicken wire)

Answer 30

Alcoholic cirrhosis

Question 31

Degree of fibrosis

Answer 31

Stage

Question 32

Degree inflammation, necrosis, and steatosis

Answer 32

Grade

Question 33

Most common cause of increased liver enzymes

Answer 33

Non-alcoholic steatohepatitis

Question 34

No inflammation, cell death, or fibrosis in

Answer 34

Non-alcoholic steatohepatitis

Question 35

Just have Microvesicular steatosis

Answer 35

Non-alcoholic steatohepatitis