Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

204 > Regulating Immunological Aspects > Flashcards

Regulating Immunological Aspects Flashcards

1
Q

What are cytokines actions?

A

Signalling by receptors depends on association with Janus kinases, tyrosine phosphorylation of signalling molecules.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cytokines are split into?

A

Type 1- IL
Type 2- IFN gamma Il 22
TNF
IL-1 Family Cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cytokines pleiotropy?

A

The higher the pleiotropy the more cell types or tissues are targeted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cytokines redundancy?

A

Different cytokines have the same effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Endothelial cells produce?

A

IL6, causing inflammatory cells to be activated, fever and acute phase protein production in the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Haptotaxis?

A

Migration following a gradient of increasing conc of immobilised molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Chemokinesis?

A

Increased movement by soluble chemokine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Haptokinesis?

A

Increase of movement induced by immobilised chemokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chemokines contain?

A

4 cysteine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Names of chemokines are determined by?

A

Spacing between first 2 determines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

For blunt chest trauma severity measure?

A

IL3/13/21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Inflammation and newborn sepsis and chorioamnionitis diagnostic use through?

A

IL6/ IL8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Therapeutic use of melanoma use?

A

IL 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Homing to skin which cytokine interaction?

A

CXCR3 of Th1 CD4 T cells interacts with CXCL9 on endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Homing to gut lamina propria cytokine interaction?

A

Th1 CD4 T cell CCL25 acts on CR9 on endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How do chemokines interact at receptor?

A

G - protein coupled chemokine receptors

17
Q

What is the diagnostic use of IL 1 beta?

A

Inflammation, ventilator associated pneumonia

18
Q

What is the diagnostic use of il 3 13 and 21?

A

Blunt chest trauma severity

19
Q

What is the diagnostic use of il 6 and 8?

A

Inflammation sepsis and chroioamnionitis

20
Q

What is the diagnostic use of il 10?

A

Large B cell lymphoma

21
Q

What is the diagnostic use of interferon gamma?

A

Tb

22
Q

Which interleukin has therapeutic use for psoriasis?

A

Il 10

23
Q

Which cytokine has therapeutic use for viral hepatitis, cancer and tuberculosis?

A

IFN alpha

24
Q

Which interleukin has therapeutic use for il 2?

A

Melanoma, renal cell carcinoma

25
Q

Which cytokine has diagnostic use for macrophage activation in CGD chronic granulomatous diseasE?

A

IFN gamma

26
Q

Which is a cytokine antagonist for therapeutic use in rheumatoid arthritis?

A

Anti TNF

204 (58 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions