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Flashcards in Renal Diagnosis and Treatment Deck (28)
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1
Q

Prerenal failure lab findings and treatment

A

Oliguria
Increased BUN to CR ratio>20:1 (kidney reaborbs urea)
Increased urine osmolarity (>500 mOsm/kg H2O)
Decreased urine Na (less than 20 mEq/L)
FeNa less than 1%
increased urine: plasma Cr ratio (>40:1)
Bland urine sediment-hyaline casts, no protein or blood

Treatment:
Give normal saline to maintain euvolemia and restore the blood pressure-not in patients with edema or ascites
Stopping antihypertensive medications may be necessary
Eliminate ACE inhibitors or NSAIDs
Swan-Ganz monitoring is indicated if patient is unstable

2
Q

Intrinsic renal failure lab findings and treatment

A

decreased BUN: Cr (less than 20:1)
Increased urine Na (>40 mEq/L)
FeNa >2% to 3%
Decreased urine osmolality (less than 350 mOsm/kg H2O)
Decreased urine:plasma Cr ratio (less than 20:1)

Treatment: Therapy is supportive, eliminate offending agent
Can try furosemide if patient is oliguric

3
Q

Postrenal failure lab findings and treatment

A

Benign urine sediment

No protein or blood in urine

Diagnosis by ultrasound (order for most AKI unless its obviously not postrenal)
Catheter will have large volume of urine

Treatment: bladder catheter and urology consultation

4
Q

ATN diagnosis

A

Urine sediment: Muddy brown casts, granular casts,

Trace proteins, no blood

5
Q

Acute glomerulonephritis diagnosis

A

Urine sediment: dysmorphic RBCs, RBCs with casts, WBCs with casts, fatty casts
Protein: 4+
Blood: 3+

Renal biopsy indicated

6
Q

Acute interstitial nephritis diagnosis

A

Urine sediment: RBCs, WBCs, WBCS with casts, eosinophils
Protein: 1+
Blood: 2+

Renal biopsy indicated

7
Q

AKI Electrolyte/Metabolite complications

A
Hyperkalemia
Hyponatremia
Hyperuricemia
Hypocalcemia (cannot activate Vitamin D)
Hyperphosphatemia
Metabolic acidosis
8
Q

Treatment of general AKI

A

Avoid medications that decrease renal blood flow (NSAIDs) or are nephrotoxic (aminoglycosides, radiocontrast agents)
Adjust medication dosages for level of renal function
Correct fluid imbalance: IV fluids or diuretics
Monitor fluids by daily weight measurements and intake-output records
Correct electrolyte imbalances
Optimize cardiac output: 120 to 140/80-90
Order dialysis: uremia, hyperkalemia, acidemia, volume overload

9
Q

Amyloidosis diagnosis and treatment

A

Diagnosis: abdominal fat pad aspiration biopsy

Treatment: underlying condition
Colcichine for prevention and treatment

10
Q

Diagnosis and treatment of Chronic kidney disease

A

Urinaylsis: examine sediment
Measure Cr clearance to estimate GFR (less than 60 signifies CKD)
CBC: normocytic normochromic anemia, thrombocytopenia
Hyperkalemia, hyperphosphatemia, hypocalcemia, metabolic acidosis, hypermagnesia

Renal ultrasound-small size of kidneys
Presence of normal sized kidneys does not exclude CKD
Possible renal biopsy

Treatment:
Low protein: .7-.8 g/kg body weight per day
Low salt diet if HTN, CHF or oliguria present
Restrict potassium, phosphate and magnesium intake

ACE inhibs: slow progression of proteinuria and reduce risk of ESRD
Can cause hyperkalemia

BP control: decreases rate of disease progression
ACE inhibs preferred

Glycemic control: prevents worsening of proteinuria

Smoking cessation

Hyperphosphatemia: calcium citrate
Oral calcium and vitamin D
Acidosis: may require bicarbonate

Anemia: EPO

Pulmonary edema: dialysis if unresponsive to diuretics

Pruritis: capscaian cream or cholestyramine and UV light

Dialysis
Transplantation is only cure

11
Q

Indications for Dialysis

A

AEIOU
Acidosis: severe

ingestion of drugs: (ELMMS)-ethylene glycol, lithium, Mg containing laxatives, methanol, salicylates
electrolyte imbalances: severe hyperkalemia and hypermagnesemia

Overload: pulmonary edema, hypertensive emergency refractory ot antihypertensive agents

Uremia: N and V, lethargy/mental deterioration, encephalopathy, seizures, pericarditis (not emergent)

12
Q

Rhabdomyolysis

A

lab findings: markedly elevated creatinine phosphokinase, hyperkalemia, hypocalcemia, hyperuricemia

Treatment: IV fluids, mannitol (osmotic diuretic), and bicarbonate (drives K back into cells)

13
Q

Proteinuria diagnosis and treatment

A

Diagnosis: Hyperlipidiemia, hypoalbunimea (edema), urine protein >3.5 g/24 hours, hypercoagulable, increased infection risk

Urine dipstick test: albumin detects concentrations of 30 mg/dL or higher (3+ equals nephrotic syndrome)

UA: RBC casts=Glomerulonephritits
WBC casts=pyelonephritis, and interstitial nephritis
Fatty casts suggest nephrotic syndrome

If proteinuria is confirmed-24 hour urine collection
Microalbuminemia: 30-300 mg/day-if positive run radioimmunoassay

Treatment: transient-no further workout
If persistent: check BP examine urine sediment
Symptomatic: ACE inhibs
Diuretics if edema
limit protein and sodium
treat hypercholestrolemia
influenza and pneumococcus
14
Q

Diagnosis, Lab and clinical findings of nephritic syndrome

A

labs: hematuria, AKI- azotemia and oliguria, Proteinuria (not in nephrotic range)

Clinical: HTN, edema

Diagnosis: urinalysis, blood studies, needle biopsy of kidney

15
Q

Diagnosis, Lab and clinical findings of nephrotic syndrome

A

lab: urine protein excretion rate greater than 3.5/24 hours
Hypoalbuninemia
Hyperlipidemia, fatty casts in urine

Clinical: edema, hypercoagulable state, increased risk of infection

Diagnosis: urinalysis, blood tests, needle biopsy

16
Q

Minimal change disease treatment

A

steroids for 4-8 weeks

17
Q

Focal segmental glomeruloscerosis treatment

A

cytotoxic agents, steroids, and immunosuppressie agents

ACE and ARBs are indicated

18
Q

Diagnosis and treatment of poststreptococcal GN

A

low complement levels, proteinuria, antisterptolysin-O

Treatment: generally self limited so treat supportively
Antihypertensives, loop diuretics for edema, steroids may be helpful

19
Q

Diagnosis and treatment of goodpastures syndrome

A

Diagnosis: crescenteric, linear immunofluroscence patter on renal biopsy
IgG anti-glomerular basement membrane Ab

Treatment: plasmapharesis, cyclophosphamide, and steroids

20
Q

HIV nephropathy diangnosis and treatment

A

Histopathology shows pattern similar to FSGS

Treatment: prednisone, ACE inhibitors, and antiretroviral therapy

21
Q

Diagnosis and treatment of AIN

A

Diagnosis: renal function tests (increased BUN and Cr)

Eosinophils in the urine suggest the diagnosis
Mild proteinuria and microscopic hematuria

Treatment: remove offending agent
steroids can help

22
Q

Diagnosis and treatment of renal papillary necrosis

A

Diagnosis: excretory urogram-note change in papilla or medulla

Treat the underlying cause and stop offending agent

23
Q

Diagnosis and treatment of ADPKD

A

Diagnosis: ultrasound

Treatment: no curative treatment
drain cysts if symptomatic, treat infection with antibiotics, control HTN

24
Q

Diagnosis and treatment of medullary sponge kidney

A

Hematuria, UTIs or nephrolithiasis

Associated withy hyperparathyroidism and parathyroid adenoma

Diagnosed by IVP

No treatment necessary, symptomatic

25
Q

Diagnosis and treatment of renal artery stenosis

A

Abdominal bruit, sudden HTN refractory to medical therapy

Diagnosis: renal arteriogram is the gold standard but contrast dye can be nephrotoxic-do not use in renal failure

MRA is new test that has high sensitivity and specificity-can be used in renal failure

Treatment: revascularization with percutaneous tarnsluminal renal angioplasty initital treatment
Bypass surgery if not successful
Concomitant ACE inhibitors and CCBs

26
Q

Neprholithiasis diagnosis, treatment and prevention

A

Calcium oxalate: bypyramidal or biconcave
uric acid: flat square plates
Struvite: rectangular prisms
Cystine: hexagon shpated crystals

Stones less than .5 cm pass spontaneously

Diagnosis:
UA: microscopic or gross hematuria
Associated UTI if pyuria or bacteriruia
Determine pH of urine

imaging: plain radiograph (KUB)-initial study choice (won’t detect cystine or uric acid stones)
CT scan is gold standard
IVP: determining if they need procedural therapy
Renal ultrasonography: cant receive radiation (pregnant)

Treatment: 
Analgesia: IV morphine, ketorolac (parenteral)
Vigorous fluid hydration
Antibiotics
a1 blockers to help pass stone

Mild to moderate pain: high fluid intake, oral analgesia wait for stone to pass spontaneously
Severe pain: IV fluids and pain control, obtain KUB and an IVP to find site of obstuction, doesn’t pass for 3 days consult urology
Ongoing obstruction and persistent pain: surgery necessary
Extracorporeal shock wave lithotripsy-best for stones greater than 5 mm and less than 2 cm (percutanous nephorlithotomy if fails)

Prevention:
High fluid intake is essential (2L of urine/day)
limit protein amount if hyperuricosuria
Limit calcium intake if calcium stones

Thiazide diruetics, allopurinol

27
Q

Diagnosis and treatment of urinary tract obstruction

A

Diagnosis: renal ultrasound is initial test-initial test for identifying hydronephrosis
KUB-reveals stones
intravenous urogram (IVP)-gold standard for ureteral obstruction-CI if pregnant, allergic or renal failure
Voiding cystourethrography-lower tract obstruction
Cystoscopy-evaluate urethra and bladder

Treatment:
Lower obstruction: urethral catheter for acute,
Dilatation or internal uretnrotomy-cause is urehtral strictures, prostatectomy if BPH
Upper urinary tract: nephrostomy tube drainage-for acute
ureteral stent-if ureteral obstruction

Acute complete obstruction: pain or renal failure-immediate therapy
Acute partial: due to stones
Chronic partial: immediate if infection, severe symptoms, renal failure or urinary retention

28
Q

Treatment of testicular torsion

A

Surgical emergency
Bilateral orchopexy and detorsion of scrotum

do not delay beyond 6 hours

Orchiectomy if nonviable testicle is found