Flashcards in Renal Transplantation (Clinical Demonstration) Deck (9)
What are the major barriers to successful transplantation?
Species differences, blood group antibodies and HLA antibodies
What are the minor barriers to successful transplantation?
Degree of HLA matching, donor characteristic, recipient characteristic, cold ischaemia time (CIT), donor type (living, dead or heart beating brain dead)
Outline the different types of HLA molecules
Class I: A, B, C
Class II, DQ, DR, DP
What are the HLA types most relevant to be matched for a kidney transplant?
HLA-A, HLA-B and HLA-DR
What are the advantages of using a living donor?
The donor is screened for medical problems and renal dysfunction, short cold ischaemia time (CIT) and the procedure can be elective
Where are HLA Class I molecules found?
On almost all cells
Where are HLA Class II molecules found?
On B cells and activated cells
What drugs may be given post-kidney transplant in order to prevent rejection?
Steroids azathioprine, MMF, cyclosporine, tarcrolimus and rapamycin