Renal Transplantation (Clinical Demonstration) Flashcards Preview

METABOLISM 2 > Renal Transplantation (Clinical Demonstration) > Flashcards

Flashcards in Renal Transplantation (Clinical Demonstration) Deck (9)
Loading flashcards...
1

What are the major barriers to successful transplantation?

Species differences, blood group antibodies and HLA antibodies

2

What are the minor barriers to successful transplantation?

Degree of HLA matching, donor characteristic, recipient characteristic, cold ischaemia time (CIT), donor type (living, dead or heart beating brain dead)

3

Outline the different types of HLA molecules

Class I: A, B, C
Class II, DQ, DR, DP

4

What are the HLA types most relevant to be matched for a kidney transplant?

HLA-A, HLA-B and HLA-DR

5

What are the advantages of using a living donor?

The donor is screened for medical problems and renal dysfunction, short cold ischaemia time (CIT) and the procedure can be elective

6

Where are HLA Class I molecules found?

On almost all cells

7

Where are HLA Class II molecules found?

On B cells and activated cells

8

What drugs may be given post-kidney transplant in order to prevent rejection?

Steroids azathioprine, MMF, cyclosporine, tarcrolimus and rapamycin

9

What are the potential complications of a kidney transplant?

Infection, cardiovascular disease, diabetes, bone issues, GI disease, cosmetic disease and tumour (organ, skin or post-transplant .. disorder)