[renal tubular disease] Flashcards

1
Q
A

renal tubular acidosis

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2
Q
A

impaired acid secretion by the kidney

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3
Q
A

4

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4
Q
A

distal tubule

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5
Q
A

proximal tubule

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6
Q
A

inability to secrete H+ ions

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7
Q
A

reduced HCO3 reabsorption (“bicarbonate leak”)

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8
Q
A

increased HCO3 conc
osmotic effect
increased flow
increased K+ secretion

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9
Q
A

IV sodium bicarbonate load

High fractional excretion

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10
Q
A

15

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11
Q
A

sodium bicarbonate >10 mmol/kg/day

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12
Q
A

fanconi syndrome

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13
Q
A

they buffer the acid in bone causing osteomalacia

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14
Q
A

Type 1

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15
Q
A

buffering of H+ ions with calcium

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16
Q
A

1

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17
Q
A

renal calculi

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18
Q
A

urine pH >5.5

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19
Q
A

sodium bicarbonate

citrate

20
Q
A

renal calcium stones

21
Q
A

RTA 1 + 2 combination

22
Q
A

hypereninaemic hypoaldosteronism

23
Q
A

H+

K+

24
Q
A

K+ sparing diuretics

25
Q
A

addisons

26
Q
A

REMOVE CAUSE
fludrocortisone
+
furosemide

27
Q
A

amino acids
glucose
Phosphate (PO4)
bicarbonate (HCO3)m

28
Q
A

proximal tubule

29
Q
A

dehydration
osteomalacia
metabolic acidosis

30
Q
A

cystinosis

31
Q
A

remove cause replace losses

32
Q
A

cystine accumulation in lysosomes

cystine deposits

33
Q
A

fanconis
visual impairment
myopathy
hypothyroid

34
Q
A

oral cysteamine

35
Q
A

Bartter syndrome

Gitelman syndrome

36
Q
A

Bartters causes hypocalaemia

Gitelmans causes Hypocalcaemia

37
Q
A

Gitelmans

38
Q
A

Bartters

39
Q
A

Bartters

40
Q
A

Gitelmans

41
Q
A

Gitelmans

42
Q
A

yes

43
Q
A

nephrocalcinosis leading to stones

44
Q
A

Indomethacin

replace K+

45
Q
A

prostaglandin synthesis inhibitor

46
Q
A

replace Mg and K+