Reproductive - Disorders of Puberty Flashcards Preview

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Flashcards in Reproductive - Disorders of Puberty Deck (34)
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1

What is the normal age range for entering puberty in girls?

8 - 13 years

2

What is the normal age range for entering puberty in boys?

9 - 14 years

3

Is delayed puberty more common in boys or girls?

Boys

4

Is precocious puberty more common in boys or girls?

Girls

5

Define what is meant by delayed puberty in girls?

The lack of any breast development by the age of 13 years

6

Define what is meant by delayed puberty in boys?

A testicular volume < 4mls by 14 years

7

What is the most common cause of delayed puberty in both sexes?

Constitutional delay

8

Is a pathological cause for delayed puberty more likely in boys or girls?

Girls

9

What are some central causes of delayed puberty, with an intact hypothalamic-pituitary axis?

Constitutional delay, chronic disease, malnutrition

10

What are some central causes of delayed puberty, caused by secondary hypogonadism?

Pituitary disease, GnRH deficiency

11

What are some peripheral causes of delayed puberty?

Turner's/Klinefelter's syndrome, bilateral testicular damage

12

What physical sign may be seen in adolescents with constitutional pubertal delay?

Short stature

13

What investigation may be useful to support a diagnosis of constitutional pubertal delay?

Bone age radiograph

14

Why should TFTs be performed in individuals with delayed puberty?

Hypothyroidism can be a cause

15

How can puberty be induced in those with constitutional pubertal delay?

A short course of oestrogen or testosterone

16

Precocious puberty is defined as signs of puberty before what age in girls?

8 years

17

Precocious puberty is defined as signs of puberty before what age in boys?

9 years

18

What are some peripheral (gonadotrophin-independent) causes of precocious puberty?

Ovarian/testicular/adrenal tumours or CAH

19

Is the cause of central precocious puberty more likely to be pathological in boys or girls?

Boys

20

What will a bone radiograph show in children with precocious puberty?

Advanced bone age

21

What imaging investigation is indicated in all boys, and girls aged < 6 years, with precocious puberty?

Pituitary MRI

22

What blood test is a reliable indicator of whether a boy has entered puberty or not?

Early morning testosterone

23

In a child with precocious puberty, very high levels of either testosterone or oestrogen with suppressed gonadotrophin levels suggests what?

Peripheral precocious puberty

24

Which gonadotrophin is the most reliable indicator of whether a child's gonadotrophins are at pubertal or pre-pubertal levels?

Serum LH

25

If the picture of precocious puberty is unclear, what stimulation test can be used?

GnRH stimulation test

26

In the GnRH stimulation test, what will happen if there is central precocious puberty?

Gonadotrophin levels will rise

27

In the GnRH stimulation test, what will happen if there is peripheral precocious puberty?

No change in gonadotrophin levels

28

What medication can be used to halt puberty in children with idiopathic precocious puberty?

Gonadotrophin agonists

29

What is the main complication of precocious puberty?

Diminished final adult height

30

How is androgen insensitivity syndrome inherited?

X linked