Reproductive System

Question 1

Androgens - what is primary

Answer 1

Testosterone is primary male androgen.

Question 2

Androgens are used to treat

Answer 2

Androgens are used to treat disorders in males and females.
Hypogonadism in males
Diseases such as cancer and HIV infection in both sexes

Question 3

Androgens what are scheudled

Answer 3

Anabolic steroids are scheduled drugs.

Question 4

Androgens contraindicated in

Answer 4

Male breast cancer or prostate cancer
Pregnancy (category X) and lactation
Transdermal drugs not used in women

Question 5

Androgens ADR

Answer 5

Hepatitis, hepatic neoplasm, cholestatic hepatitis, jaundice, and hepatocellular carcinoma
Men: gynecomastia, reduced sperm levels, decreased libido at high levels, depression
Women: menstrual irregularities, virilization

Question 6

Androgens prescibed for

Answer 6

Primary hypogonadal males
Hypogonadotropic hypogonadism
Male climacteric

Question 7

Androgens rational drug slection

Answer 7

Intramuscular (IM) vs oral vs transdermal vs newer nasal form
Aqueous vs oil IM preparations

Question 8

Androgens monitoring

Answer 8

Serum testosterone levels, lipids, liver function, complete blood count
Men need prostate-specific antigen and digital prostate examinations

Question 9

Indications that the increased risk of prostate

Answer 9

cancer with long-term replacement is not as great as thought (unless already present)

Question 10

Statin therapy can decrease

Answer 10

testosterone on a statistically significant level, but clinically insignificant level
Drops 19 ng/dL for men and 11.5 ng/dL for women
Normal range is 250 to 110 ng/dL for men, 2 to 45 ng/dL for women

Question 11

Erectile Dysfunction what to identify

Answer 11

Identify etiology
Identify CV risk factors
Initiate medical therapy

Question 12

Phosphodiesterase type 5 inhibitors (PDE5)

examples

Answer 12

Sildenafil citrate (Viagra), tadalafil (Cialis), vardenafil (Levitra)

Question 13

Phosphodiesterase type 5 inhibitors (PDE5)

contraindications

Answer 13

In patients using nitrates because of a risk of severe, even fatal hypotension
Alpha blockers have additive hypotension effect

Question 14

Phosphodiesterase type 5 inhibitors (PDE5)

other info

Answer 14

Small studies in women are inconclusive

Used in neonatal intensive care unit for persistent pulmonary hypertension

Question 15

Addyi for

Answer 15

For women with diagnosed with severe sexual dysfunction (serotonin and dopamine agonist)
Black Box warning for severe hypotension when used with alcohol

Question 16

Addyi not a same

Answer 16

day effect as with PDE5 inhibitors for men; takes about 3 months for full effect, and many do not benefit at all