Fatty acids in membrane lipids (8)
Myristic acid Palmitic acid Pamitoleic Stearic Oleic Linoleic Linolenic Arachidonic
Myristic acid
14 carbons, saturated
Palmitic acid
16 carbons, saturated
Palmitoleic acid
16 carbons
Cis unsaturated at
(9)C=C(10)
Stearic acid
18 carbons, saturated
Oleic acid
18 carbons
Double bond C9-10
Linoleic acid
18 carbons
C9=10
C12=13
Linolenic acid
18 carbons
C9=10
C12=13
C15=16
Arachidonic acid
20 carbons C5=6 C8=9 C11=12 C14=15
Fatty acids in membrane lipids with 16 carbons
Palmitic and palmitoleic acids
Fatty acids in membrane lipids with 18 carbons (4)
Stearic
Oleic
Linoleic
Linolenic
Trans double bond
Left side; stiffer
Cis double bond
Right side; kink in tail
Aquaporins
Allow water and some solutes to cross membrane
6 alpha helices
10 different tissue specific family members (rbc, brain, eye, kidney, lung etc)
Cystic fibrosis
Caused by mutation in Cl- transporter (CFTR)
Caused downstream alteration in fluid movement across membrane
HYPP
Hyperkalenic periodic paralysis
AQH
Mutation in skeletal muscle Na+ channel
Gating and proper closure
Uric acid
End product of purine metabolism
Converted to allantoin in liver prior to excretion - transporter from blood to sub cellular site of enzyme uricase
Uric acid + uricase = allantoin
Dalmatian mutation in uric acid transporter
SLC2A9
Hyperuricosemia, hyperuricosuria, and stones
Crystallization of insoluble excess uric acid in urine
