Review Of Wk 1 - Degen Vs Inflam Joint Conditions

Question 1

Is OA or RA more common

Answer 1

OA

Question 2

Age of onset in OA and RA

Answer 2

OA - later life
RA - 30-60

Question 3

Speed of onset in OA and RA

Answer 3

OA - slow - yrs
RA - rapid - wks/months

Question 4

Joint symptoms in OA vs RA

Answer 4

OA - aching and tender, little swelling
RA - painful, swollen, stiff

Question 5

Are OA and RA symmetrical or asymmetrical

Answer 5

OA asymmetrical
RA symmetrical

Question 6

Duration of morning joint stiffness in RA and OA

Answer 6

OA - less than 1 hr
RA - more than 1 hr

Question 7

Whole body symptoms in OA and RA

Answer 7

OA - none
RA - fatigue + general illness

Question 8

OA treatments

Answer 8

Weight loss/exercise
Paracetamol
COX2 inhibitors
NSAIDs
Intra articular hylauronic acid
Intra articular steroids
Joint replacement surgery

Question 9

Extra articular RA signs

Answer 9

Vasculitic rash
Scleritis
Subcutaneous nodules

Question 10

1st step of RA pathogenesis

Answer 10

Abnormal protein citrullinatklm
Generation of anti CCP and anti PAD4 autoantibodies

Question 11

What causes pannus

Answer 11

Cytokines cause proliferation of type b synoviocytes and fibroblasts in subintima
Cytokines induce synovial fibroblasts to express RANKL -> osteoclasts production
CD4T helper cell infiltration

Question 12

RA anchor drug

Answer 12

Methotrexate

Question 13

Are osteomalacia and osteoporosis pts generally well or unwell

Answer 13

Osteomalacia - unwell
Osteoporosis - well

Question 14

When is pain felt in osteomalacia and osteoporosis

Answer 14

Osteomalacia - chronic ache
Osteoporosis - only after fracture

Question 15

What condition causes loosers zones

Answer 15

Osteomalacia

Question 16

How are alkaline phosphatase and serum phosphorus levels effected by osteomalacia

Answer 16

AP increased
SP decreased

Question 17

How are alkaline phosphatase and serum phosphorus levels effected by osteoporosis

Answer 17

Both normal