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MKSAP KEY POINTS > Rhem Qs > Flashcards

Rhem Qs Flashcards

1
Q

Henoch-Schönlein purpura - affects? Caused by? Lab findings? What comfirms the diagnosis?

A

skin, joints, kidneys, and gastrointestinal tract

Immune complex disease

Active Urine sedimentl C4 low, IgA elevated

Deposition of IgA on a skin
biopsy

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2
Q

Hemochromatosis - affect on joints?

A

OA-like arthropathy BUT affects second and third metacarpophalangeal (MCP) or wrist joints.

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3
Q

Anti-synthase syndrome?

If suspected on PE, should get what imaging test?

A

anti–Jo-1 plus two of the following clinical features:

myositis, interstitial lung disease, Raynaud phenomenon, nonerosive inflammatory arthritis, and mechanic’s hands.

CXR

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4
Q

Tofacitinib - used to treat? Will cause what lab abnormality?

A

RA; elevation of all components of lipid panel

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5
Q

Patients with Sjögren syndrome are at risk of developing what cancer?

A

Lymphoma (B-cell and MALT)

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6
Q

Long term consequence of FMF?

A

AA amylodosis

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7
Q

Pt with interstitial lung disease from diffuse cutaneous systemic sclerosis - start this medication?

A

cyclophosphamide

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8
Q

Eosinophilic granulomatosis with polyangiitis is characterized by? (4)

A

eosinophilia,
migratory pulmonary infiltrates,
purpuric skin rash,
mononeuritis multiplex in the setting of antecedent atopy.

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9
Q

immunosuppressant agent that preferentially targets T cells?

A

Cyclosporine

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10
Q

Diffuse idiopathic skeletal hyperostosis?

A

noninflammatory condition defined by the presence of flowing osteophytes involving the anterolateral aspect of the thoracic spine at four or more contiguous vertebre

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11
Q

prodromal stage of hepatitis B virus infection?

A

rapid-onset symmetric polyarthritis, (present before frank jaundice)

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12
Q

inclusion body myositis - age of onset? muscles involved? symmetry?

Usual CK level?

A

> 50, distal and proximal, mostly symmetric

<1000

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13
Q

This improves the symptoms of dry eyes in patients with primary Sjögren syndrome?

A

Topical cyclosporine

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14
Q

used to treat allergic conjunctivitis?

A

Olopatadine drops

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15
Q

Hydroxycloroquine - benefit in SLE? (4)

A

Reduces disease activity
improves survival
reduces risk of SLE-related thrombosis
Reduses risk of MI

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16
Q

When to start urate lowering therapy for you? (4)

A
  • 2+ attacks within a year
  • An attack + CKD
  • An attack tophi
  • An attack with a history of urolithiasis
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17
Q

Treatment of polymyalgia rheumatica?

A

Low dose (10-20mg) prednisone

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18
Q

Anyone with reactive athritis should be tested for?

A

Chlamydia

19
Q

Milwaukee shoulder syndrome - age/sex? caused by? Charaterized by? Historical clues?

A

Women 70+

calcium phosphate deposition

pain, stiffness, and swelling that occurs gradually.

preceding trauma or history of overuse on the affected side

20
Q

IgG4-related disease is characterized by (histologically)?

A

lymphoplasmacytic infiltration

21
Q

Eosinophilia myalgia syndrome - presents with? Caused by?

A
  • fasciitis and dermal induration
  • neuropathy
  • myopathy

linked to consuming contaminated L-tryptophan

22
Q

Morphea is characterized by ?

A

ocalized area of skin thickening

23
Q

initial treatment of choice for patients with new-onset, rapidly progressive, or erosive rheumatoid arthritis?

For non-erosive disease?

A

Methotrexate

Hydroxychloroquine

24
Q

anti-U1-RNP antibodies suggest?

Also must have 3/5?

A
  • Raynaud phenomenon,
  • edema of the hands,
  • sclerodactyly,
  • synovitis, and
  • myositis
25
Q

Triad for DAH?

A

hypoxemia, new infiltrates found on chest radiograph, and decreasing hematocrit

26
Q

Löfgren syndrome?

Characterized by?

Treat with?

A

self-limited sarcoidosis

acute arthritis, bilateral hilar lymphadenopathy, and erythema nodosum

NSAIDs or low-dose prednisone

27
Q

Nonbiologic disease-modifying antirheumatic drugs (DMARDs) such as methotrexate and sulfasalazine - role in axial disease? in peripheral arthritis?

A

Not efficacious

may be considered

28
Q

Women with dermatomyositis may have an increased risk of?

A

Ovarian cancer

29
Q

Strong risk factor for PAN?

A

HBV

30
Q

Diagnosis of PAN is best established by demonstrating what on biopsy? Or this on imaging findings?

A

necrotizing arteritis

characteristic medium-sized artery aneurysms and stenoses on imaging studies of the mesenteric or renal arteries

31
Q

People with gout should eat MORE of this?

A

Low-fat dairy

32
Q

Study that could be appropriate if thromboangiitis obliterans (“Buerger disease”) were suspected?

A

Digital arteriography

33
Q

U1-ribonucleoprotein antibodies are associated with?

A

Mixed Connective tissue disease

34
Q

primary angiitis of the central nervous system (PACNS). Diagnosis and treatment?

A

Brain biopsy; glucocorticoids and cyclophosphamide

35
Q

Test to confirm Takayasu arteritis?

A

arteriography of the aorta and its branches

36
Q

SLE treatment that needs to be stopped during pregnancy?

That do not need to be stopped?

A

Mycophenolate mofetil

Prednisone and hydroxychloroquine

37
Q

The presence of these antibodies is sufficient to establish a diagnosis of granulomatosis with polyangiitis in patients with these 3 findings?

A

antiproteinase 3 antibodies

classic upper airway manifestations, pulmonary infiltrates/nodules, and glomerulonephritis

38
Q

Antimyeloperoxidase antibodies are associated with? (3)

A

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome), and rapidly progressive glomerulonephritis.

39
Q

Blood pressure medications that lower uric acid levels?

A

losartan and calcium channel blockers

40
Q

Pt with severe tophaceous gout and persistent hyperuricemia and has not responded to oral urate-lowering therapy, including the xanthine oxidase inhibitors allopurinol and febuxostat. Next Med?

A

pegloticase

41
Q

Scleroderma renal crisis presents with? (organ affected, vitals, labs)

Treatment?

A

Acute onset of oliguric kidney disease and severe hypertension, mild proteinuria, urinalysis with few cells or casts, microangiopathic hemolytic anemia, and thrombocytopenia.

ACE inhibitor

42
Q

In patients with systemic sclerosis, malabsorption is often due to? Test?

A

bacterial overgrowth. glucose hydrogen breath test.

43
Q

Treatment for high-risk polymyalgia rheumatica?

A

Methotrexate+ prednisone

MKSAP KEY POINTS (19 decks)

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