Rheumatoid arthritis Flashcards Preview

Musculoskeletal > Rheumatoid arthritis > Flashcards

Flashcards in Rheumatoid arthritis Deck (13):
1

What is rheumatoid arthritis?

A chronic systemic inflammatory disease, characterised by potentially deforming symmetrical polyarthritis and extra-articular features

2

What joints are most commonly affected in RA?

Small joints of the hands and feet and the cervical spine
Larger joints such as the hips, knees, shoulders and elbows can also be affected

3

Which auto-antibodies can be used to aid diagnosis of RA?

Anti-CCP
Rheumatoid factor

4

Which blood tests might be abnormal in RA?

ESR and CRP are usually raised

5

What is the pathogenesis of RA?

Synovium becomes laden with macrophages, fibroblasts, and multi-nucleated giant cells
Synovial membrane (pannus) expands and actively invades and erodes surrounding bone and cartilage
As a result, there is less production of useful synovial fluid and the joint swells

6

What are the clinical features of RA?

Synovitis
Morning stiffness
Joint pain
Joint deformity
Systemic malaise e.g. fatigue

7

What is synovium?

Synovium lines joint capsules and is the metabolically active part of joints

8

What are some of the systemic manifestations of RA?

Scleritis
Pleural effusion
Anaemia of chronic illness
Thrombocytosis
Ischaemic heart disease

9

How does RA present radiologically?

Xrays tend to show a hypotrophic artritis (rather than the hypertrophic picture with OA) with loss of joint space but little or no osteophyte formation, sclerosis or bone cysts Periarticular erosions occur

10

What are 'rheumatoid nodules' and where do they occur?

Nodules consisting of areas of vasculitis and fibroblasts made from transformed macrophages
These tend to occur at pressure points
N.B. rheumatoid vasculitis tends to be benign

11

Why might ultrasound be useful in diagnosis or assessment of RA?

Can be used to identify synovitis that can't be determined by palpation

12

What are some of the clinical signs of RA in the joints?

Swelling
Tenderness
Reduced range of movement
Muscle wasting around affected joints
Deformities in late stage of disease

13

Which genes are related to RA?

HLA DR4
HLA DR1