Flashcards in Seronegative arthropathies Deck (26)
What are seronegative arthropathies?
A family of inflammatory arthritides characterized by involvement of both the spine and joints
What are some of the features of seronegative arthropathies?
Sacroiliac and spinal involvement
Dactylitis (sausage digits)
What is enthesitis?
Inflammation of the enthuses, the sites where ligament or tendon insert into the bone
What are some extra-articular features of seronegative arthropathies?
Ocular involvement e.g. conjunctivitis
Which gene are seronegative arthropathies associated with?
When is the typical period of onset for ankylosing spondylitis?
Late teens/early adulthood
What are the symptoms of ankylosing spondylitis?
Back pain and stiffness that improves with exercise and isn't relieved by rest
Pain and swelling elsewhere e.g. hips, knees and ribs
What are some of the treatments for ankylosing spondylitis?
Anti TNF treatment – Infliximab, adalimumab
Which joints are usually affected in ankylosing spondylitis?
What is Schober's test?
A test used to assess the patient's ability to flex their back
The distance between two fingers placed on the lower back is measured while standing
The patient is then asked to touch their toes, and the increase in distance between fingers is measured
What is psoriatic arthritis?
Arthritis associated with psoriasis
Only in a small number of cases does the arthritis precede the psoriasis
What is onycholysis?
The separating of the nail from the nail bed
What are the features of psoriatic arthritis?
Nail involvement - pitting, onycholysis
In which seronegative arthropathy can "whiskering" and/or a "pencil in cup" deformity be seen on Xray?
What is reactive arthritis?
An autoimmune disease which causes arthritis to develop in response to an infection from elsewhere (cross-reactivity)
What are the most common causative organisms for reactive arthritis?
What are some of the clinical features of reactive arthritis?
General Symptoms (fever, fatigue, malaise)
Asymmetrical monoarthritis or oligoarthritis
What are some examples of mucocutaneous lesions?
Keratodema blenorrhagica (vesicular lesions on palms and soles)
Circinate balanitis (dermatitis on penis)
Painless oral ulcers
What is the triad of Reiter's syndrome?
What extra-articular features are involved in ankylosing spondylitis?
AV node block
Which gender is more commonly affected in ankylosing spondylitis?
Which gender is more commonly affected in psoriatic arthritis?
No gender preference
What is the treatment for psoriatic arthritis?
Anti TNF – etanercept
What blood tests would indicate psoriatic arthritis?
Negative rheumatoid factor
Raised inflammatory parameters
When do symptoms of reactive arthritis occur?
4-5 weeks following infection