Rheumatoid Arthritis Flashcards Preview

PPS 946 > Rheumatoid Arthritis > Flashcards

Flashcards in Rheumatoid Arthritis Deck (13):
1

Pannus

Inflamed, proliferating tissue

2

CD28 binds to what to become activated?

CD80/86

3

An ACR/EULAR score greater than ____ is a diagnosis of RA.

6

4

Non-Pharm Tx of RA

Smoking cessation
Rest
Physical therapy
Weight loss
Surgery

5

What HLA antigens put you at a higher risk of developing RA?

HLA-DRB1
HLA-DRB4

6

What are some comorbidities that put you at a higher risk for developing RA?

T1 and T2DM
Inflammatory lung disease
Dyslipidemia

7

What are some protective environmental factors for RA?

Fish oil, olive oil
Alcohol consumption
Schizophrenia

8

Describe Synovitis.

Infiltration of inflammatory cells into the synovial tissue

Pannus present

9

What CD factors must bind for T cells to be activated?

CD80/86 and CD28

10

What are some possible drug targets for RA?

B-cells
TNF-alpha
IL-1 and IL-6

11

Joints involved in RA

Metacarpophalangeal, proximal interphalangeal, second through fifth metatarsophalangeal, thumb interphalangeal, wrist

12

Describe the difference between RA and osteoarthritis.

RA is morning stiffness longer than 30 minutes
RA doesn't increase with age
RA shows an increase in ESR
RA is symmetrical joint inflammation

13

What are comorbities that you need to manage in RA?

Infection
Osteoporosis
CVD