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Flashcards in Gout Deck (10):
1

What is uric acid a byproduct of?

Purine metabolism

2

What serum levels define hyperurecemia?

Levels greater than 7 mg/dL

3

What are two ways we can target hyperurecemia?

Inhibiting xanthine oxidase
Prevent reabsorption

4

Describe the pathway of developing gouty arthritis.

Hyperuricemia leads to precipitation of monosodium urate (MSU). These MSU crystals lead to inflammation.

5

Name risk factors for Gout.

Hyperuricemia
Male
High purine diet (red meats, shellfish)
Beer and alcohol
Obesity and the metabolic syndrome
CKD
Solid organ transplantation
Medications

6

Name medications that can lead to gouty arthritis

Diuretics (thiazides, loops)
Calcineurin inhibitors
Low-dose salicylates
Niacin (vitamin B3)

7

Describe Acute Gouty Arthritis "Flare"

Severe pain, fever, warmth/swelling

Usually monoarticular
With or without tophi

Rapid onset and lasts for about 3-10 days

8

Chronic Gouty Arthritis

Polyarticular
Tophi (urate cyrstal aggregates)
Nephropathy in severe cases

9

How long do you wait to start ULT after an acute attack?

6-8 weeks

10

How do you treat severe pain?

Combination therapy