Flashcards in Gout Deck (10):
What is uric acid a byproduct of?
What serum levels define hyperurecemia?
Levels greater than 7 mg/dL
What are two ways we can target hyperurecemia?
Inhibiting xanthine oxidase
Describe the pathway of developing gouty arthritis.
Hyperuricemia leads to precipitation of monosodium urate (MSU). These MSU crystals lead to inflammation.
Name risk factors for Gout.
High purine diet (red meats, shellfish)
Beer and alcohol
Obesity and the metabolic syndrome
Solid organ transplantation
Name medications that can lead to gouty arthritis
Diuretics (thiazides, loops)
Niacin (vitamin B3)
Describe Acute Gouty Arthritis "Flare"
Severe pain, fever, warmth/swelling
With or without tophi
Rapid onset and lasts for about 3-10 days
Chronic Gouty Arthritis
Tophi (urate cyrstal aggregates)
Nephropathy in severe cases
How long do you wait to start ULT after an acute attack?