Rheumatoid Arthritis Flashcards Preview

Pharm 1 Final Exam > Rheumatoid Arthritis > Flashcards

Flashcards in Rheumatoid Arthritis Deck (40):
1

What type of disease is RA?

systemic inflammatory disease
autoimmune disease

2

What are the symptoms of RA

joint inflammation (BILATERALLY)
whole person is sick
fatigue
general malaise
low grade temperature

3

Pharmacological goals of tx of RA

Provide symptomatic relief
Delay progression of disorder

4

some of drugs used for tx of RA are also used for

antirejection drugs in organ transplant
and management in IBD

5

provides rapid, symptomatic relief of inflammation and pain in RA

NSAIDS

6

steriods

antiinflammatories

7

provide symptomatic relief of inflammation and pain

glucocorticoids

8

What are the routes glucocorticoids are administered?

IV, oral or intraarticular (injected into inflammed joint)

9

Side effects of steriods

immunosupression

10

Potassium rich diets include

bananas potatoes and apricot

11

DMARDS stands for

disease modifying anti-Rheumatic drugs

12

Function of DMARDS

slow joint degeneration
slow progression of disease

13

Downfalls of DMARDS

take a while to work
very toxic

14

Which is cheaper DMARS biologic/nonbiologic

nonbiologic

15

How do antimalarial drugs work against RA? Example of antimalarial drgu

theyre antiinflammatories
Hydroxycholorquine/Plaquenil

16

Hydroxycholorquine/Plaquenil SE***

retinal damage/blindness***

17

DMARDS I- Nonbiologic Include

Rheumatrex
Arva
Antiinflammatories: - sulfasalazine
Antimalarial drugs- hydroxychloroquine/plaquinil
tetracyclines

18

Drug used for IBS, GI discomfort, liver damage, bone marrow supression

Q: which class

Sulfasalazine
non-major biologic DMARDS-1

19

What is the drug of choice for RA?

rhumatrex

20

how often is rhumatrex given?

once a week

21

rhumatrex other uses

cancer
psoriasis
other immune diseases

22

which drug is a folic acid analog

rhumatrex

23

DMARDS II

Major biologic response modifiers
(immune modulators)

24

etanercept/ENBREL function
Q2: what category does it fall under
Q3: route

immunosupressant
DMARDS II
injectable

25

etanercept/ENBREL function SE**

**local reaction injection issues
risk of infection
skin reax
immunosupressant
heart failure
blood dyscrasias
increases risk of herpes zoster

26

etanercept/ENBREL class

DMARDS II major biologic

27

DMARDS III

minor nonbiologic and biologic

Gold salts
penicillamine
Cytotoxic drugs- Imuran
Antirejection drugs

28

Gold salts comes with a risk of

toxicity
rashes
stomatitis
renal toxicity
blood dyscrasias
inflamed liver- hepatitis
GI disturbances
(When you give gold you are killing cells)

29

Penicillamine SE

can cause bone marrow supression
toxicity

30

Penicillamine is what type of drug

DMARDS III

31

penicillamine
Class

NOT an antibiotic
DMARDS III

32

When you give elemenets that kill cells it is called

elemental pharmacology

33

Anti rejection drugs SE

come with a risk of infection
hepatotoxicity
nephrotoxicity
hirsuitism

34

Antirejection drugs are what class

DMARDS III

35

people who cant tolerate rheumatrex/dont want to take injectable would take

Xeljanx

36

Xeljanx can be taken with biologic/nonbiologic?
Q2: what other medications

Nonbiological DMARDS
Rheumatrex and Methotrexate.

37

Xeljanz function

decreases immune response to supress inflammation

38

Xeljanz cannot be taken with

biologic DMARDS
immunosupressants (cyclosporine and azathioprine)

39

cytotoxic drug used as chemo

penicilamine
DMARDS III

40

people who cannot tolerate rhumatrex or methotrexate can use

Xeljanz