What is the greatest environmental risk factor for RA?
How does the timecourse differ in inflammatory arthritis and mechanical arthritis?
Mechanical arthritis takes much longer and develops insipidusly over months
What is reactive arthritis?
Immune complex mediated arthritis and myalgia post acute infection
What is naproxen?
An NSAID commonly used in arthritis'
What does lupus differ from RA on examination?
Synovitis is rarely present in lupus where it's a feature of RA
Arthralgia is more common in lupus
How are corticosteroids administered in RA?
What is the best imaging to assess damage caused by inflammatory arthritis?
How do you Ix for inflammatory arthritis?
Rheumatoid factor, anti-Citrullinated Protein ab, anti-ANA ab
FBE - ?anaemia
What are the biological DMARDs?
TNF inhibitors - etanercept, infliximab
B cell inhibitor - rituximab
Cell adhesion inhibitor - abatacept
IL-6 inhibitor -Tocilizumab
What are the DMARDs?
What are some DDx for pain and stiffness in small joints of the hands?
How has the methods of RA treatment changed?
Start with combination (methotrexate, sulphasalazine, hydroxychloroquine)
Then wean to maintenance therapy
What is ACR20?
Clinical (patient and physician opinion) and radiological evaluation of treatment efficacy for a overall 20% improvement
How in RA treated pharmacologically?
Disease modifying anti-rheumatic drugs
What is the combination therapy for RA?
How does methotrexate compare to the biologics in treating RA?
Not much different
What is the limitation of the new biologic drugs?
The immune system adapts to circumvent the suppression
How does RA synovitis feel on palpation?