Rheumatoid Arthritis (core) Flashcards Preview

Hugh's MD2 Intersession 2 > Rheumatoid Arthritis (core) > Flashcards

Flashcards in Rheumatoid Arthritis (core) Deck (18)
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1

What is the greatest environmental risk factor for RA?

Smoking

2

How does the timecourse differ in inflammatory arthritis and mechanical arthritis?

Mechanical arthritis takes much longer and develops insipidusly over months

3

What is reactive arthritis?

Immune complex mediated arthritis and myalgia post acute infection

4

What is naproxen?

An NSAID commonly used in arthritis'

5

What does lupus differ from RA on examination?

Synovitis is rarely present in lupus where it's a feature of RA

Arthralgia is more common in lupus

6

How are corticosteroids administered in RA?

Oral

Intra-articular

7

What is the best imaging to assess damage caused by inflammatory arthritis?

MRI

8

How do you Ix for inflammatory arthritis?

Rheumatoid factor, anti-Citrullinated Protein ab, anti-ANA ab

CRP, ESR

FBE - ?anaemia

MRI

8

What are the biological DMARDs?

TNF inhibitors - etanercept, infliximab

B cell inhibitor - rituximab

Cell adhesion inhibitor - abatacept

IL-6 inhibitor -Tocilizumab

9

What are the DMARDs?

Hydrochloroquine

Sulphasalazine

Methotrexate

Leflunomide

10

What are some DDx for pain and stiffness in small joints of the hands?

RA

Reactive arthritis

Lupus

11

How has the methods of RA treatment changed?

Start with combination (methotrexate, sulphasalazine, hydroxychloroquine)

Then wean to maintenance therapy

12

What is ACR20?

Clinical (patient and physician opinion) and radiological evaluation of treatment efficacy for a overall 20% improvement

14

How in RA treated pharmacologically?

Analgesic

Anti-inflammatory drugs 

Disease modifying anti-rheumatic drugs

15

What is the combination therapy for RA?

Methotrexate

Hydroxylchloroquine

Sulphasalazine

16

How does methotrexate compare to the biologics in treating RA?

Not much different

17

What is the limitation of the new biologic drugs?

The immune system adapts to circumvent the suppression

18

How does RA synovitis feel on palpation?

Boggy