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Rizk Review > Rheumatology > Flashcards

Rheumatology Flashcards

(103 cards)

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1
Q

Pattern of AM stiffness in OA?

A

Lasts < 30 minutes

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2
Q

2 XR findings for OA?

A

Osteophytes, Joint narrowing

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3
Q

Pattern of arthritis in Hereditary Hemochromatosis?

A

2nd + 3rd MCP joint

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4
Q

XR appearance of arthritis in Hereditary Hemochromatosis?

A

Hook-shaped osteophytes

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5
Q

Best initial treatment for OA?

A

Scheduled acetaminophen

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6
Q

Only role for corticosteroids in setting of OA?

A

Intra-articular injection … (never systemic)

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7
Q

Pattern of AM stiffness in RA?

A

Lasts > 45 minutes

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8
Q

Patient with HX of RA presents with swelling in popliteal fossa – diagnosis?

A

Baker cyst

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9
Q

Diagnostic test for Baker cyst?

A

Need to distinguish from popliteal artery aneurysm … US

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10
Q

Extra-articular manifestations of RA are more common in patients with high titers of …

A

RF

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11
Q

What treatment typically worsens RA nodules?

A

Methotrexate

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12
Q

2 characteristics of RA pleural effusion?

A

High LDH, Low glucose (< 30)

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13
Q

Are RA pleural effusions exudative or transudative?

A

Exudative

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14
Q

Ocular manifestation of RA?

A

Episcleritis

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15
Q

Triad of clinical symptoms seen in Felty Syndrome?

A

RA, Splenomegaly, Neutropenia

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16
Q

3 aspects of treatment for Felty Syndrome?

A

Methotrexate, Corticosteroids, Splenectomy

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17
Q

56 yo female with HX of RA develops R knee pain; PE shows fever, R knee redness/swelling – diagnosis?

A

Septic arthritis

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18
Q

First step in management of Septic arthritis?

A

Joint aspiration

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19
Q

What is the only medication that slows the progression of joint destruction in RA?

A

DMARDs … Methotrexate

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20
Q

AE of sulfasalazine?

A

Reversible oligospermia

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21
Q

Major AE of hydroxyurea?

A

Retinopathy

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22
Q

Monthly monitoring required for patients on hydroxyurea?

A

Ophthalmology visits

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23
Q

AE of D-penicillinamine?

A

Bronchiolitis obliterans PNA

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24
Q

3 conditions that contraindicate methotrexate use?

A

Renal disease, ETOH abuse, Liver failure

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25
Medication that is contraindicated with methotrexate use?
TMP-SMX
26
Which cytokine is a significant mediator of inflammation in RA?
TNFa
27
6 aspects of clinical presentation for Adult Still’s Disease?
Fever, Arthritis, Rash during febrile episodes, Sore throat, LAD, Splenomegaly
28
Characteristic lab finding in setting of Adult Still’s Disease?
Increased ferritin
29
Most common cause of death in Ehlers-Danlos Syndrome?
Aortic aneurysm rupture
30
Malignancy associated with Sjogren Syndrome?
Lymphoma
31
Diagnostic test for Sjogren Syndrome?
Lip biopsy of minor salivary glands
32
Appearance of biopsy in Sjogren Syndrome?
T lymphocyte infiltration
33
DOC for Raynaud’s phenomenon in Systemic sclerosis?
CCBs
34
Most common cause of death in Systemic sclerosis?
Pulmonary HTN
35
What accounts for development of pulmonary HTN in Systemic sclerosis?
Intimal proliferation
36
Patient with PMHX of scleroderma is diagnosed with acute renal failure, severe HTN, edema – diagnosis?
Scleroderma renal crisis
37
Best treatment for Scleroderma renal crisis?
ACEIs
38
Change to GI that is pathognomonic for scleroderma?
Wide-mouth diverticula
39
Best treatment for SIBO?
10 days of ciprofloxacin
40
What is most specific skin finding for dermatomyositis?
Grotton papules
41
Characteristic of Grotton papules?
Spares the interdigital spaces
42
Lab value that is always seen in Polymyalgia Rheumatica?
ESR \> 50
43
Best test for establishing diagnosis of ankylosing spondylitis?
Pelvic XR
44
2 aspects of clinical presentation for ankylosing spondylitis?
Iritis, Sacroilitis
45
Heart murmur associated with ankylosing spondylitis?
AR
46
Best treatment for ankylosing spondylitis?
Anti-TNFa
47
Patient develops painful keratotic papules + plaques of soles, penis; Reports recent HX of urethritis, arthritis – diagnosis?
Reiter’s Syndrome
48
Most common pathogen responsible for Reiter’s Syndrome?
Chlamydia
49
3 DOC for psoriatic arthritis?
Anti-TNFa, Methotrexate, NSAIDs
50
MSK disorder associated with Crohn’s Disease?
SI joint arthritis
51
Location of pathogen in joint in reactive arthritis?
Aseptic effusion … No growth of pathogen in joint
52
Location of pathogen in joint in Whipple’s Disease?
Synovial tissues
53
What is required for definitive diagnosis of gout?
Aspiration of fluid
54
DOC for overproduction of uric acid causing gout?
Allopurinol
55
DOC for underexcretion of uric acid causing gout?
Probenecid
56
2 conditions associated with Pseudogout?
Hyperparathyroidism, Hemochromatosis
57
Which joint is most affected by Pseudogout?
Knee
58
XR appearance seen in setting of Pseudogout?
Chondrocalcinosis
59
Description of chondrocalcinosis seen in Pseudogout XR?
Linear calcification of joint cartilage
60
Best treatment for Pseudogout?
NSAIDs, Intra-articular corticosteroids
61
Most SN lab for SLE?
ANA
62
Most SP lab for SLE?
Anti-dsDNA
63
Antibody associated with Mixed Connective Tissue Disease?
Anti-U1-RNP
64
Which lab finding is most characteristic of Anti-Phospholipid Syndrome?
Prolonged PTT
65
Which antibody is needed on ELISA for diagnosis of Anti-Phospholipid Syndrome?
Anti-Cardiolipin Antibody
66
Characteristic of rash in vasculitis?
Palpable
67
2 examples of large-vessel vasculitis?
Takayasu arteritis, Giant cell arteritis
68
Change to vision in Giant cell arteritis?
Amaurosis fugax … transient loss of vision
69
Clinical presentation of Takayasu arteritis?
Raynaud’s phenomenon
70
Which vessels are most affected in Takayasu arteritis?
Aortic arch vessels
71
2 DOC for treatment of Takayasu arteritis?
Glucocorticoids, CCBs
72
1 example of medium-vessel vasculitis?
Polyarteritis nodosum
73
Pathogen associated with Polyarteritis nodosum?
Hepatitis B
74
Which organ system is always spared in Polyarteritis nodosum?
Lungs
75
Most common site of aneurysm in Polyarteritis nodosum?
SMA
76
Is P-ANCA or C-ANCA (+) in Polyarteritis nodosum?
Both are (-)
77
3 examples of small-vessel vasculitis?
Microscopic polyarteritis, Wegner’s granulomatosis, Churg-Strauss disease
78
Is P-ANCA or C-ANCA (+) in Microscopic polyarteritis?
P-ANCA
79
Renal manifestation of Microscopic polyarteritis?
Rapidly Progressive GN
80
Is P-ANCA or C-ANCA (+) in Churg-Strauss disease?
P-ANCA
81
Hallmark lab test seen in Churg-Strauss disease?
Eosinophilia
82
Clinical presentation of Churg-Strauss disease?
Adult-onset asthma
83
Is P-ANCA or C-ANCA (+) in Wegner’s granulomatosis?
C-ANCA
84
Alternate name for Wegner’s granulomatosis?
Granulomatosis with polyangiitis
85
Which 3 organ systems are most affected by Wegner’s granulomatosis?
Sinuses, Lungs, Kidneys
86
2 DOC for treatment of Wegner’s granulomatosis?
Corticosteroids, Cyclophosphamide
87
Pathogen associated with cryoglobulinemia?
Hepatitis C
88
Which PE finding will differentiate Rotator Cuff Tendinitis from Rotator Cuff Tear?
Tear = (+) drop arm test
89
Which 2 motions are limited by Biceps tendinitis?
Elbow flexion, Supination
90
3 aspects of treatment for De Quervain’s Tenosynovitis?
Spica splint, Steroid injection, NSAIDs
91
Which 2 tendons are affected by De Quervain’s Tenosynovitis?
EBP + APL
92
Best diagnostic test for Carpal Tunnel Syndrome?
EMG
93
Best initial treatment for Carpal Tunnel Syndrome?
Immobilization
94
Patient presents with clenched fist; Recently punched someone in mouth – pathogen responsible for symptoms?
Staph, Eikenella
95
Patient presents with clenched fist; Recently punched someone in mouth – best treatment?
Ampicillin-Sulbactam
96
Best treatment for plantar fasciitis?
Stretching
97
Patient presents with pain to upper medial aspect of tibia that increases with climbing stairs – diagnosis?
Anserine bursitis
98
2 aspects of treatment for Anserine bursitis?
Steroid injection, Quadriceps training
99
Best test for diagnosis of avascular necrosis?
MRI
100
Best treatment for trochanteric bursitis?
Stretching, Steroid injection
101
Best treatment for lumbar strain?
Exercise therapy, NSAIDs
102
MRI appearance of spinal stenosis?
103
3 conditions associated with Cauda Equina Syndrome?
Paget Disease, Ankylosing spondylitis, Tumors

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