What is the pattern of ghrelin secretion?
Cyclical - rises before meals and drops after
What other therapeutic does oxyntomodulin have a synergic effect with?
Which cells are the main producers of CCK?
I cells of the small intestine
Why can’t CCK work as a therapeutic?
Though it lowers meal size, the number of meals increase therefore the overall calorie consumption is high
What is the bodies’ response to weight loss in the long term?
Attempts to defend the original weight
- increase ghrelin
- decrease amylin, CCK and PYY
Where is insulin-like peptide 5 produced in the greatest quantity?
Does ghrelin signal hunger or satiety?
What is liraglutide?
Long acting GLP-1 analogue
What receptor does oxyntomodulin act through?
The GLP-1 receptor
Which cells of the arcuate nucleus produce the satiety peptides?
The POMC cells
What was the effect of GLP-1 treatment in humans?
Increased the feeling of fullness
Is insulin-like peptide 5 a hunger or satiety hormone?
What is the drawback with PYY therapy?
Which part of the GIT produces the greatest amount of ghrelin?
Is CCK a hunger or satiety signal?
What is the mechanism of action of GIP?
Promotes triglyceride clearance from the circulation by activating lipoprotein lipase
What is the effect of PYY?
Reduced food intake
What are the hunger peptides produced by the arcuate nucleus?
Which peptide does ghrelin act through in the arcuate nucleus?
What are the satiety peptides produced by the arcuate nucleus?
What is the effect of the microbiota on obesity?
Increase FA metabolism and storage of calories in fat
What is the effect of oxyntomodulin?
Reduce food intake and increase energy expenditure
What is the name of the master controller of hunger and satiety in the hypothalamus?
The arcuate nucleus