Rush Lewis System

Question 1

type 1 precursor

Answer 1

gal-glunac-gal-R

Question 2

composition of h soluble substance

Answer 2

gal(fuc)-glunac-gal-R

Question 3

composition of Lea antigen

Answer 3

gal-glunac(fuc)-gal-R

Question 4

composition Leb antigen

Answer 4

gal(fuc)-glunac(fuc)-gal-R

Question 5

explain how Lea and Leb works

Answer 5

Lea only happens when FUC attaches to glunac first and its the final form

Leb is when FUC attaches to gal first and another attaches to glunac

Question 6

these are substances and can serve as substrate for lewis enzyme formung the two types of Leb antigens

Answer 6

A and B soluble substances
Aleb and Bleb

Question 7

which lewis antigens are no longer substrates for ABO and Se enzymes

Answer 7

Lea and Leb

fucosyltransferase 2 and 3 are for lewis and se

fucosyltrans 1 and 2 are for H expression and se

Question 8

3 types of lewis phenotypes

Answer 8

Le a+b-
Le a-b+
Le a-b-

Question 9

genotype for the lewis phenotype:
Le a+b-
Le a-b+
Le a-b-

Answer 9

Lele or LeLe sese
Lele/LeLe Sese/SeSe
lele

Question 10

Se gene and Le gene has what transferase and what does it cause?

Answer 10

fucosyltransferase, causes competition with each other

Question 11

this is frequently detected in antibody screenung and occur frequently in what tuoe of demographic

Answer 11

lewis antibodies
pregnant women

Question 12

what individuals make lots of lewis antibodies and are they naturally occuring?

Answer 12

Le a-b-
and yes

Question 13

immunoglobin of lewis antibodies

Answer 13

IgM

Question 14

why is lewis antibodies not a concern clinically

Answer 14

lewis antigens in plasma or saliva usually gets rid of them

Question 15

characteristics of Anti-Lea

Answer 15

most common antibody
IgM (some IgG components and some IgG)
in vitro hemolysis via complement
rare HTR

Question 16

characteristics of Anti-Leb

Answer 16

IgM
Complement activator (weaker than Lea)
Produced by Le a-b- and Le a+b-

Question 17

4 reasons why lewis antibodies are insignificant

Answer 17

easily neutralized via plas/saliva antigens
easily dissociate
IgM so cant do anything in warm body
they cant cross placenta

Question 18

what chromosome is lewis system found

Answer 18

chromsome 19

Question 19

none secretor lewis phenotypes

Answer 19

Le a+b-
Le a-b-

Question 20

the only secretor phenotype of lewis

Answer 20

Le a-b+

Question 21

is Lea and Leb still formed in Le -b+? why?

Answer 21

Lea is just weak and Leb predominates

Question 22

precurso substance type for genes:
H
Se
Le

Answer 22

H type 2 (B1-4)
Se type 1 (B1-3)
Le type 1 (B1-3)