sarcoma de ewing Flashcards by Alejandra de la rosa

Q

segunda neoplasia osea + frecuente en pediatria

A

sarcoma de ewing

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Q

sarcoma de ewing
edad
genes

A

5-25 años
EWS/ETS

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Q

sarcoma de ewing
localización + frecuente

A

diafisis

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Q

imagen radiologica caracteristica

A

en capas de tela de cebolla

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Q

sarcoma de ewing
celulas
que se puede ver?

A

pequeñas, redonda y azules
se pueden ver rosetas

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Q

marcadores que se deben de hacer

A

CD99
FLI-1
NKX.2

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Q

IHQ

A

vimentina
CK

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Q

tipo de neoplasia

A

monotona

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Q

macador + sensible para sarcoma de ewing

A

NKX.2

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Q

como les va?

A

mal, es muy agresivo

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Q

IHQ negativa (4)

A

miogenina
CD45
cromogranina
MyoD1

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Q

biologia molecular
translocacion

A

t(11:22) (q24;q12)

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Q

factores de pronostico
edad dx

A

favorable: <10
desfavorable: >18

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Q

factores de pronostico
sitio

A

favorable: extremidad distal y proximal
desfavorable: pelvis

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Q

factores de pronostico
tamaño de tumor

A

<8 cm es buen pronostico

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Q

tumor oseo maligno + frecuente en adulto es

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A

metastasis por carcinoma (pulmon, mama, prostata)

Q

tumor oseo maligno primario + frecuente es

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A

mieloma multiple