What does oxidative stress result in?
Increased free radicals which cause endothelial damage and decrease NO availability causing vasoconstriction and damage to blood vessels
What is the result of increased TGFbeta?
Scarring in kidney and eye, less ECM breakdown, BM of glomerulus thickens
What affect can diabetes have on the arterioles in the glomerulus?
Paralysis of tone which is much bigger in the afferent so much wider than efferent so more blood enters glomerulus increasing GFR- use RAAS inhibitor to lower pressure