Scenario 17 Flashcards Preview

Medicine Year 2 > Scenario 17 > Flashcards

Flashcards in Scenario 17 Deck (64)
Loading flashcards...

What does oxidative stress result in?

Increased free radicals which cause endothelial damage and decrease NO availability causing vasoconstriction and damage to blood vessels


What is the result of increased TGFbeta?

Scarring in kidney and eye, less ECM breakdown, BM of glomerulus thickens 


What affect can diabetes have on the arterioles in the glomerulus?

Paralysis of tone which is much bigger in the afferent so much wider than efferent so more blood enters glomerulus increasing GFR- use RAAS inhibitor to lower pressure