schizophrenia Flashcards

(36 cards)

1
Q

How to diagnose sz

A

~ Both ICD-11 + DSM-5 state that psychotic symptoms should be present in patient for at least one month.
~ DSM-5 requiring that symptoms continue for up to 6 months

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2
Q

What is sz

A

chronic’ mental illness ongoing, significantly impedes daily life and requires constant medical attention

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3
Q

How does the ICD-11 define sz

A

psychotic disorder characterised by severe + significant impairments in determining what is real and what is fantasy
~ at least 2 positive or negative symptoms are present in the patient

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4
Q

How does the DSM-5 define sz differently to DSM 4

A

DSM 5 = experienced at least 2 of the positive or negative symptoms
DSM 4 = at least 1 positive symptom was present in the patient

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5
Q

what do positive symptoms cause

A

alarm + distress to both the patient and other people as they are active manifestations of the illness

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6
Q

What are 2 positive symptoms

A

Hallucinations: voices talking to the patient, often critically and with negative intent; seeing distortions in what is around them e.g. in facial expressions; seeing things that are not there

Delusions: misguided or irrational beliefs (patient’s belief that they are Jesus), paranoia (the CIA are spying on them), unfounded ideas as to their own ability or even their body (they have magic powers/ are possessed by an evil spirit

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7
Q

what are negative symptoms

A

withdrawal from life/loss of normal functioning

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8
Q

examples of 2 negative symptoms

A

Speech poverty: (alogia) not being able to take part in a conversation due to delayed responses, lack of vocabulary, vagueness); producing speech which is incoherent, (e.g. inventing words), doesn’t follow the rules of grammar

Avolition: (apathy) person takes no interest in life or in themselves; they neglect personal hygiene, neglect their work or education, neglect activities that they usually find pleasurable; involves a complete lack of motivation to achieve even the simplest of tasks

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9
Q

what is validity in sz diagnosis

A

realness/trueness of what is being measured

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10
Q

what causes a diagnosis to be invalid in sz

A

clinician, having reviewed the patient’s symptoms, gives a diagnosis of an illness that does not actually fit those symptoms

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11
Q

How can a diagnosis be reliable in sz

A

= must show consistency + agreement across diagnosing clinicians (same set of symptoms must be given, same diagnosis regardless of who is doing the diagnosing)

~ Inter-rater reliability: if more than 1 clinician is diagnosing the same patient then they should both/all agree as to the diagnosis
-> Issues with reliability
occur when (as does
happen) clinicians
disagree as to the
diagnosis

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12
Q

How can a diagnosis be unreliable in sz

A

clinicians don’t use the same diagnostic tools e.g. one clinician uses the DSM + other uses the ICD, regardless of year of publication of both of these manuals

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13
Q

What are 2 researchers that investigated reliability/validity in diagnosis

A

validity= Rosenhan
reliability =Santelmann et al

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14
Q

What was Rosenhans study into validity of sz diagnosis (+-)

A
  • field experiment
  • he + 8 confederates reported false symptoms and were all (but one) admitted to mental hospitals with a diagnosis of schizophrenia
    + high ecological validity (naturalistic setting+ naive pps), insight the findings gave into the ‘sticky’ label of diagnosis
  • lack of ethical validity due to deception involved + lack of control in field experiments
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15
Q

What was Santelmann et al study into reliability of sz diagnosis (+-)

A
  • meta-analysis of 25 studies with a total sample of 7912 patients diagnosed by different raters
  • found that reliability of sz diagnosis had consistently lower inter-rater reliability than diagnosis of major depressive disorder + bpd

+ reliability due to large sample size and robust quantitative data

  • potential selection bias regarding the studies chosen for the meta-analysis
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16
Q

What is co-morbidity

A

when one patient is diagnosed with two or more mental illness
- difficulties in diagnosing a co-morbid patient is trying to ascertain the extent of one illness over another particularly when there is symptom overlap (Is this depression or is it part of patient X’s schizophrenia)

17
Q

What is symptom overlap + example

A

when two or more illnesses share some of the same symptoms
e.g. avolition (a negative symptom of schizophrenia) overlaps with symptoms of depression - lethargy, lack of motivation, neglecting personal hygiene etc

18
Q

What is 1 issue for clinicians when faced with symptom overlap

A

the DSM and the ICD use different criteria to classify the same symptoms
e.g. the DSM might produce a diagnosis of schizophrenia whereas the ICD diagnosis might be bi-polar disorder for the same set of symptoms

19
Q

study that supports co-morbidity (+-)

A

Buckley et al. (2009) found sz co-morbidities: 50% for depression; 47% for substance abuse disorder; 29% for PTSD; 23% for OCD; 15% for panic disorder
+ support it provides for co-morbidity as a diagnosis issue
- lack of clarity as to why depression has higher rates of co-morbidity than other disorders

20
Q

study that goes supports both co-morbidity+ symptom overlap (+-)

A

Newson et al. (2021) - a meta-analysis of 107,349 that DSM-5 diagnostic criteria do not sufficiently distinguish between schizophrenic symptoms and those of co-morbid/overlapping disorders such as depression
+ secondary data research process is swift and cost-effective
- lack of insight into why symptom overlap and co-morbidity occur (no explanatory power)

21
Q

culture bias in diagnosis

A

clinician does not take a patient’s culture into account when making a diagnosis

22
Q

Gender bias in diagnosis
(3)

A

= any instances of a person being diagnosed according to their gender, rather than their symptoms
E.g. a female is not diagnosed with sz even when she presents symptoms as clinician may view her as a ‘hysterical female’ rather than taking her symptoms seriously (alpha bias)

= clinician doesn’t take a patient’s gender into account when making a diagnosis e.g. male models of health are used to diagnose a woman

= not pay enough attention to the fact that the risk factors for developing sz are different for male + females so there should be no ‘one size fits all’ approach (beta bias)

23
Q

who supports gender bias and culture bias

A

gender bias= Hambrecht et al
culture bias= Schwartz et al

24
Q

what was Schwartz et al study into culture bias (+-)

A

African Americans are 2.4 times more likely to be diagnosed with sz compared with non-African American individuals -> culture bias in the diagnostic process and cultural insensitivity on the part of clinicians

+ good application (findings of this research could be used to inform diagnosis going forward)

  • use of rating scales to assess symptoms (fine detail of symptoms is lost when having to apply a standardised measure to them)
25
what was Hambrecht et al into gender bias (+-)
males + females are equally at risk of developing sz but sz is under-diagnosed in women + representative nature of the sample, addressing issues such as alpha bias and beta bias in diagnosis - explanations as to why schizophrenia is under-diagnosed in women and what can be done to address this
26
what is heritability
= extent to which a condition/ trait has been passed on generationally through families via genes
27
What did Gottesman do and find
conducted research into the heritability of sz + found a concordance rate of: - 48% for sz between MZ - 17% for DZ - 9% for siblings - 6% for parents - 1% for general pop
28
Gottesman conclusion
closer the genetic link between you and someone with sz, the higher the chance you have of also developing the illness
29
how has candidate genes contributed to understanding the genetic basis of sz
The genes which may increase a person’s risk of developing sz are known as candidate genes + as there are several of them sz is referred to as polygenic ~ no single gene that has (so far) been identified as causing sz
30
What are the 2 researches that investigated the genetic basis of schizophrenia
- McCarroll et al - Haraldsson
31
What did McCarroll et al find
analysed the genomes of 65,000 people and 700 postmortem brains and found that the strongest known genetic risk for schizophrenia comes from the gene known as C4
32
What did Haraldsson find Haraldsson
conducted meta-analysis which found strong evidence for the heritability of sz and that some candidate genes in combination with each other result in a person having an increased vulnerability to schizophrenia compared to other combinations of candidate genes
33
2 Strengths of the genetic basis of schizophrenia Strengths
+ Methods used to measure a genetic explanation for sz are clinical, objective and not affected by sources of bias (individual differences)-> good reliability and validity + There is now a huge and compelling body of research evidence which points to genetics playing a key role in the development of sz
34
2 Weaknesses of the genetic basis of schizophrenia
- Genetics is an explanation of sz but it is not the explanation: if sz was purely biological then concordance rates for MZ twins would be 100% which no research has ever found - symptoms of sz are varied and will not present in exactly the same way per person - absence of a biomarker means that from a genetic perspective it is very difficult to know definitively if a patient acc has sz or if they have another disorder altogether
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