Schizophrenia Flashcards Preview

PT2T1 > Schizophrenia > Flashcards

Flashcards in Schizophrenia Deck (11)

What are the 4 A's originally associated as the hallmarks of schizophrenia?

Autism - social withdrawal

Ambivalence - lack of motivation

Affect - inappropriate or flat

Association - loose and disorganized


DSM5 Criteria for Schizophrenia?

Continuous signs of disturbance for at least 6 months and at least 2 or more symptoms for most of 1 month: 



-disorganized speech

-grossly disorganized or catatonic behavior

-Negative symptoms (alogia, affective flattening, avolition)


+Social/Occupational Dysfunction



Briefly describe the 5 Schizophrenia Spectrum Disorders?

1) Delusional Disorder: one or more delusions of 1 month or longer

2) Brief Psychotic Disorder: psychotic symptoms at least 1 day but less than 1 month; often in response to stressor

3) Schizophreniform Disorder: Criteria A symptoms >1 month but <6 months

4) Schizoaffective Disorder: psychotic symptoms (only for 2 weeks) + Mood disorder symptoms more of the time

5) Substance/Medication induced psychotic disorder


Positive Symptoms of Schizophrenia

Delusions - firm, false, fied ideas including ideas of reference

Disorganization - tangentially, incoherent, loose association, word salad

Inappropriate affect

Grossly disorganized or catatonic behavior


Hallucinations - false perceptions 


NEgative symptoms of Schizophrenia

Blunted Affect

Alogia - poverty of speech or speech content

Avolition - lack of will and motivation to do things 

Negative Symptoms can be primary or secondary (secondary to antipsychotic meds)  


Describe some of the other features of schizophrenia?

Relational problems - social interactions and intimacy

***Cognitive Dysfunction - attention/vigilance, processing speed, problem solving, learning and memory, social cognition




What is the Modified Da Hypothesis of Schizophrenia? 

POsitive symptoms may be mediated by Da excess in Limbic regions

Negative symptoms may be mediated by decreased Da in Prefrontal areas 

Side effects are caused by Anti-Da effects of medications in the BG 


What are some factors predicting poor prognosis in schizophrenia? 

Early onset 

no precipitating factors and insidious onset

Poor premorbid functioning

Withdrawn, autistic behavior

Family history

Negative symptoms 


What are the first-line treatments to reduce positivy psychotic symptoms? What's the difference between the 2 categories of drugs used? 

Older - Typical - 1st Generation Antipsychotics: Chlorpromazine, Perphenazine, Haloperidol  all work through D2 blockade and have EPS


Newer - Atypical - 2nd generation Antipsychotics: Olanzapine, Risperidone, Quetiapine all work with varying Da affinity and have more metabolic side effects


When/who would you use Clozapine for? 

Clozapine is a unique atypical that should be offered to people with persistent and clinically significant positve symptoms in spite of treatment with other antipsychotics aka non-responders


What is the model for "recovery"?

also talked about in addiction

Want symptom remission and return to functioning 

is a continual PROCESS rather than an end state

Strength-based vs symptom based 

Hope, Respect, Empowerment